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• W1983410040 abstract "Abstract: We have studied the inhibitory effect of aloe emodin on hepatic stellate cells activation and proliferation, as these cells play a key role in the pathogenesis of hepatic fibrosis. Rat hepatic stellate cells were activated by contact with plastic dishes, resulting in their transformation into myofibroblast‐like cells. Primary hepatic stellate cells were exposed to aloe emodin (1–10 μg/ml). Possible cytotoxic effects were measured on stellate cells and hepatocytes using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. The effects of aloe emodin on production of type I collagen and smooth muscle cell α‐actin were examined at the same concentration, by quantitative immunoprecipitation. Antiproliferative effects were examined by bromodeoxyuridine incorporation. Aloe emodin at 10 μg/ml restored the morphological changes characteristic of activated primary stellate cells, reduced DNA synthesis to 95% of control hepatic stellate cells at 10 μg/ml without affecting cell viability, and inhibited type I collagen production and smooth muscle α‐actin expression by 86.77% and 99%, respectively, which suggest that aloe emodin is a potent inhibitor of stellate cell transformation." @default.
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• W1983410040 date "2002-04-01" @default.
• W1983410040 modified "2023-10-18" @default.
• W1983410040 title "Aloe Emodin Suppresses Myofibroblastic Differentiation of Rat Hepatic Stellate Cells in Primary Culture" @default.
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• W1983410040 doi "https://doi.org/10.1034/j.1600-0773.2002.900404.x" @default.
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