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• W1983419410 abstract "Osteoporosis is a common disease with genetic component. It has been shown that polymorphic Sp1 site is associated with osteoporosis. We tried to evaluate the effects of HRT and alendronate on BMD in patients with Col1A1 Sp1 binding site polymorphism and its possible role in bone collagen turnover. Prospective cohort clinical trial Non-smoking otherwise healthy postmenopausal women (n: 60) who had not received any kind of HRT for at least 3 years onset of menopause were randomized to 0.625 mg conjugated estrogen/2.5 mg medroxyprogesterone (n: 31) or once weekly oral alendronate 70 mg for 12 months(n: 29). BMD by DEXA was measured at lumbar spine and femur neck initially and 18th month of treatment. Col1A1 Sp1 binding site polymorphism was studied by PCR-RFLP method and the examiners were unaware of the BMD results and all were Ss. The mean age, weight, length of menopausal period was similar between both groups. Both at the lumbar spine and at femur neck Ss heterozygotes had similar BMD values of Z-score units. The increase in BMD Z-scores was lower in HRT group compared to alendronate. Moreover alendronate was particularly effective in Ss heterozygotes compared to HRT. It has been shown that osteoporotic fractures were strongly associated with the Col1A1 s allele. Our preliminary data supports that Col1A1 s allele is associated with lower BMD compared to normal women. Furthermore, HRT had lower increase in BMD scores following 18 months of treatment compared to alndronate regimen in Col1A1 s allele individuals. Our study therefore may provide evidence that the Sp1 polymorphism may ameliorate the effects anti-osteoporotic regimens on BMD. Thus, suggesting that different regimens may be used to support the bone strength and decrease the osteoporotic fractures. Moreover Col1A1 Sp1 binding site polymorphism seems to be important in choosing the appropriate regimen for optimal BMD increase." @default.
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• W1983419410 date "2005-09-01" @default.
• W1983419410 modified "2023-10-16" @default.
• W1983419410 title "Effects of Hormone Replacement Therapy (HRT) and Alendronate on Bone Mineral Density (BMD) in Patients With Col 1 A1 Sp 1 Binding Site Polymorphism a Prospective Randomized Study" @default.
• W1983419410 doi "https://doi.org/10.1016/j.fertnstert.2005.07.591" @default.
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