Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983442932> ?p ?o ?g. }
- W1983442932 abstract "There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrupted interactions are hypothesized to be mediated by molecules, termed morphostats, which diffuse through the tissue to determine cell phenotype and maintain tissue architecture. We developed a computer simulation based on simple properties of cell renewal and morphostats. Under the computer simulation, the disruption of the morphostat gradient in the stroma generated epithelial precursors of cancer without any mutation in the epithelium. The model is consistent with the possibility that the accumulation of genetic and epigenetic changes found in tumors could arise after the formation of a founder population of aberrant cells, defined as cells that are created by low or insufficient morphostat levels and that no longer respond to morphostat concentrations. Because the model is biologically plausible, we hope that these results will stimulate further experiments." @default.
- W1983442932 created "2016-06-24" @default.
- W1983442932 creator A5001740944 @default.
- W1983442932 creator A5012489838 @default.
- W1983442932 creator A5024988697 @default.
- W1983442932 creator A5027267648 @default.
- W1983442932 creator A5048819576 @default.
- W1983442932 creator A5068866514 @default.
- W1983442932 date "2009-03-23" @default.
- W1983442932 modified "2023-10-03" @default.
- W1983442932 title "Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats" @default.
- W1983442932 cites W1720193968 @default.
- W1983442932 cites W1979985168 @default.
- W1983442932 cites W1980661496 @default.
- W1983442932 cites W1987905586 @default.
- W1983442932 cites W1991154912 @default.
- W1983442932 cites W1998305183 @default.
- W1983442932 cites W2006067863 @default.
- W1983442932 cites W2010069724 @default.
- W1983442932 cites W2011053154 @default.
- W1983442932 cites W2016009669 @default.
- W1983442932 cites W2017482101 @default.
- W1983442932 cites W2024289194 @default.
- W1983442932 cites W2027583149 @default.
- W1983442932 cites W2028708296 @default.
- W1983442932 cites W2029857102 @default.
- W1983442932 cites W2029939216 @default.
- W1983442932 cites W2035238501 @default.
- W1983442932 cites W2035809306 @default.
- W1983442932 cites W2045484383 @default.
- W1983442932 cites W2058078233 @default.
- W1983442932 cites W2059509996 @default.
- W1983442932 cites W2070431772 @default.
- W1983442932 cites W2072596846 @default.
- W1983442932 cites W2078615559 @default.
- W1983442932 cites W2093101935 @default.
- W1983442932 cites W2096127904 @default.
- W1983442932 cites W2096295696 @default.
- W1983442932 cites W2107648723 @default.
- W1983442932 cites W2110807009 @default.
- W1983442932 cites W2113284016 @default.
- W1983442932 cites W2138157271 @default.
- W1983442932 cites W2142216488 @default.
- W1983442932 cites W2148249556 @default.
- W1983442932 cites W2166969772 @default.
- W1983442932 cites W2219736375 @default.
- W1983442932 cites W2252393595 @default.
- W1983442932 cites W4212887994 @default.
- W1983442932 doi "https://doi.org/10.1186/1471-2407-9-89" @default.
- W1983442932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2663766" @default.
- W1983442932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19309499" @default.
- W1983442932 hasPublicationYear "2009" @default.
- W1983442932 type Work @default.
- W1983442932 sameAs 1983442932 @default.
- W1983442932 citedByCount "36" @default.
- W1983442932 countsByYear W19834429322012 @default.
- W1983442932 countsByYear W19834429322013 @default.
- W1983442932 countsByYear W19834429322014 @default.
- W1983442932 countsByYear W19834429322016 @default.
- W1983442932 countsByYear W19834429322017 @default.
- W1983442932 countsByYear W19834429322018 @default.
- W1983442932 countsByYear W19834429322020 @default.
- W1983442932 countsByYear W19834429322022 @default.
- W1983442932 countsByYear W19834429322023 @default.
- W1983442932 crossrefType "journal-article" @default.
- W1983442932 hasAuthorship W1983442932A5001740944 @default.
- W1983442932 hasAuthorship W1983442932A5012489838 @default.
- W1983442932 hasAuthorship W1983442932A5024988697 @default.
- W1983442932 hasAuthorship W1983442932A5027267648 @default.
- W1983442932 hasAuthorship W1983442932A5048819576 @default.
- W1983442932 hasAuthorship W1983442932A5068866514 @default.
- W1983442932 hasBestOaLocation W19834429321 @default.
- W1983442932 hasConcept C104317684 @default.
- W1983442932 hasConcept C121608353 @default.
- W1983442932 hasConcept C127716648 @default.
- W1983442932 hasConcept C142724271 @default.
- W1983442932 hasConcept C1491633281 @default.
- W1983442932 hasConcept C16930146 @default.
- W1983442932 hasConcept C203014093 @default.
- W1983442932 hasConcept C204232928 @default.
- W1983442932 hasConcept C28328180 @default.
- W1983442932 hasConcept C2908647359 @default.
- W1983442932 hasConcept C41091548 @default.
- W1983442932 hasConcept C501734568 @default.
- W1983442932 hasConcept C502942594 @default.
- W1983442932 hasConcept C52124034 @default.
- W1983442932 hasConcept C529295009 @default.
- W1983442932 hasConcept C54355233 @default.
- W1983442932 hasConcept C555283112 @default.
- W1983442932 hasConcept C70721500 @default.
- W1983442932 hasConcept C71924100 @default.
- W1983442932 hasConcept C86803240 @default.
- W1983442932 hasConcept C95444343 @default.
- W1983442932 hasConcept C99454951 @default.
- W1983442932 hasConceptScore W1983442932C104317684 @default.
- W1983442932 hasConceptScore W1983442932C121608353 @default.
- W1983442932 hasConceptScore W1983442932C127716648 @default.
- W1983442932 hasConceptScore W1983442932C142724271 @default.
- W1983442932 hasConceptScore W1983442932C1491633281 @default.
- W1983442932 hasConceptScore W1983442932C16930146 @default.