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• W1983443319 endingPage "17" @default.
• W1983443319 startingPage "5" @default.
• W1983443319 abstract "HIV infection of CD4+ T cells in culture results in the production of virus and induction of cell killing by apoptosis. Such a cytopathic effect is observed during infection with syncytium-inducing or non-syncytium-inducing HIV isolates. Apoptosis is triggered by the interaction of the cell membrane-expressed HIV envelope glycoprotein heterodimer gp120-gp41 complex (external and transmembrane glycoprotein complex) with the CD4 receptor. Here we demonstrate an experimental model for the induction of apoptosis independent of HIV infection, using transiently transfected HeLa cells with the HIV1 env gene as effector cells and the CD4+ MOLT4-T4 T cells as target cells. Results obtained confirm that the induction of apoptosis requires the membrane expression of the two HIV env gene products, gp120 and gp41. Single amino acid point mutations of the envelope products that affect binding to the CD4 receptor or the fusion process abrogate the capacity of the gp120-gp41 complex to induce apoptosis. Interestingly, a point mutation in the V3 loop which inhibits fusion without affecting CD4 binding also results in the abrogation of apoptosis. These observations indicate that the induction of apoptosis is an intrinsic property of the cell membrane-expressed gp120-gp41 complex, and thus should be considered as one of the functions of HIV env gene products." @default.
• W1983443319 created "2016-06-24" @default.
• W1983443319 creator A5006408418 @default.
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• W1983443319 creator A5031756347 @default.
• W1983443319 creator A5056516116 @default.
• W1983443319 date "1995-01-01" @default.
• W1983443319 modified "2023-10-18" @default.
• W1983443319 title "Membrane-expressed HIV envelope glycoprotein heterodimer is a powerful inducer of cell death in uninfected CD4+ target cells" @default.
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• W1983443319 doi "https://doi.org/10.1016/0923-2516(96)80585-1" @default.
• W1983443319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7754236" @default.
• W1983443319 hasPublicationYear "1995" @default.
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