FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983455887> ?p ?o ?g. }

• W1983455887 endingPage "645" @default.
• W1983455887 startingPage "636" @default.
• W1983455887 abstract "Helicobacter pylori colonizes the human stomach and contributes to chronic inflammation of the gastric mucosa. H. pylori persistence occurs because of insufficient eradication by phagocytic cells. A key factor of H. pylori, cholesterol-α-glucosyltransferase encoded by capJ that extracts host cholesterol and converts it to cholesteryl glucosides, is important to evade host immunity. Here, we examined whether phagocytic trafficking in macrophages was perturbed by capJ-carrying H. pylori. J774A.1 cells were infected with H. pylori at a multiplicity of infection of 50. Live-cell imaging and confocal microscopic analysis were applied to monitor the phagocytic trafficking events. The viability of H. pylori inside macrophages was determined by using gentamicin colony-forming unit assay. The phagocytic routes were characterized by using trafficking-intervention compounds. Wild type (WT) H. pylori exhibited more delayed entry into macrophages and also arrested phagosome maturation more than did capJ knockout mutant. Pretreatment of genistein and LY294002 prior to H. pylori infection reduced the internalization of WT but not capJ-knockout H. pylori in macrophages. Cholesterol glucosylation by H. pylori interferes with phagosome trafficking via a lipid-raft and PI3K-dependent manner, which retards engulfment of bacteria for prolonged intracellular survival of H. pylori." @default.
• W1983455887 created "2016-06-24" @default.
• W1983455887 creator A5005009504 @default.
• W1983455887 creator A5020503630 @default.
• W1983455887 creator A5044975030 @default.
• W1983455887 creator A5057178901 @default.
• W1983455887 creator A5069810438 @default.
• W1983455887 creator A5072216114 @default.
• W1983455887 date "2016-10-01" @default.
• W1983455887 modified "2023-10-14" @default.
• W1983455887 title "Cholesterol glucosylation by Helicobacter pylori delays internalization and arrests phagosome maturation in macrophages" @default.
• W1983455887 cites W12147719 @default.
• W1983455887 cites W1602614750 @default.
• W1983455887 cites W1972306593 @default.
• W1983455887 cites W1973232347 @default.
• W1983455887 cites W1999587546 @default.
• W1983455887 cites W2015751436 @default.
• W1983455887 cites W2017886031 @default.
• W1983455887 cites W2019978786 @default.
• W1983455887 cites W2022948175 @default.
• W1983455887 cites W2025070028 @default.
• W1983455887 cites W2029894860 @default.
• W1983455887 cites W2056247789 @default.
• W1983455887 cites W2094168277 @default.
• W1983455887 cites W2100254103 @default.
• W1983455887 cites W2111948699 @default.
• W1983455887 cites W2114581080 @default.
• W1983455887 cites W2115993724 @default.
• W1983455887 cites W2118522916 @default.
• W1983455887 cites W2118655973 @default.
• W1983455887 cites W2120640870 @default.
• W1983455887 cites W2147579496 @default.
• W1983455887 cites W2151488850 @default.
• W1983455887 cites W2158019484 @default.
• W1983455887 cites W2165679020 @default.
• W1983455887 cites W4210981094 @default.
• W1983455887 doi "https://doi.org/10.1016/j.jmii.2014.05.011" @default.
• W1983455887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25070282" @default.
• W1983455887 hasPublicationYear "2016" @default.
• W1983455887 type Work @default.
• W1983455887 sameAs 1983455887 @default.
• W1983455887 citedByCount "38" @default.
• W1983455887 countsByYear W19834558872015 @default.
• W1983455887 countsByYear W19834558872016 @default.
• W1983455887 countsByYear W19834558872017 @default.
• W1983455887 countsByYear W19834558872018 @default.
• W1983455887 countsByYear W19834558872019 @default.
• W1983455887 countsByYear W19834558872020 @default.
• W1983455887 countsByYear W19834558872021 @default.
• W1983455887 countsByYear W19834558872022 @default.
• W1983455887 countsByYear W19834558872023 @default.
• W1983455887 crossrefType "journal-article" @default.
• W1983455887 hasAuthorship W1983455887A5005009504 @default.
• W1983455887 hasAuthorship W1983455887A5020503630 @default.
• W1983455887 hasAuthorship W1983455887A5044975030 @default.
• W1983455887 hasAuthorship W1983455887A5057178901 @default.
• W1983455887 hasAuthorship W1983455887A5069810438 @default.
• W1983455887 hasAuthorship W1983455887A5072216114 @default.
• W1983455887 hasBestOaLocation W19834558871 @default.
• W1983455887 hasConcept C139770010 @default.
• W1983455887 hasConcept C1491633281 @default.
• W1983455887 hasConcept C160448771 @default.
• W1983455887 hasConcept C161478664 @default.
• W1983455887 hasConcept C202751555 @default.
• W1983455887 hasConcept C203014093 @default.
• W1983455887 hasConcept C2776409635 @default.
• W1983455887 hasConcept C2776914184 @default.
• W1983455887 hasConcept C2779244956 @default.
• W1983455887 hasConcept C54355233 @default.
• W1983455887 hasConcept C55493867 @default.
• W1983455887 hasConcept C86803240 @default.
• W1983455887 hasConcept C89423630 @default.
• W1983455887 hasConceptScore W1983455887C139770010 @default.
• W1983455887 hasConceptScore W1983455887C1491633281 @default.
• W1983455887 hasConceptScore W1983455887C160448771 @default.
• W1983455887 hasConceptScore W1983455887C161478664 @default.
• W1983455887 hasConceptScore W1983455887C202751555 @default.
• W1983455887 hasConceptScore W1983455887C203014093 @default.
• W1983455887 hasConceptScore W1983455887C2776409635 @default.
• W1983455887 hasConceptScore W1983455887C2776914184 @default.
• W1983455887 hasConceptScore W1983455887C2779244956 @default.
• W1983455887 hasConceptScore W1983455887C54355233 @default.
• W1983455887 hasConceptScore W1983455887C55493867 @default.
• W1983455887 hasConceptScore W1983455887C86803240 @default.
• W1983455887 hasConceptScore W1983455887C89423630 @default.
• W1983455887 hasFunder F4320311687 @default.
• W1983455887 hasFunder F4320321040 @default.
• W1983455887 hasFunder F4320323092 @default.
• W1983455887 hasFunder F4320324301 @default.
• W1983455887 hasIssue "5" @default.
• W1983455887 hasLocation W19834558871 @default.
• W1983455887 hasLocation W19834558872 @default.
• W1983455887 hasOpenAccess W1983455887 @default.
• W1983455887 hasPrimaryLocation W19834558871 @default.
• W1983455887 hasRelatedWork W2021522213 @default.
• W1983455887 hasRelatedWork W2115012080 @default.
• W1983455887 hasRelatedWork W2396460212 @default.
• W1983455887 hasRelatedWork W2409386328 @default.

• next