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- W1983456891 endingPage "1247" @default.
- W1983456891 startingPage "1233" @default.
- W1983456891 abstract "Animal models of chronic kidney disease (CKD) are important experimental tools that are used to investigate novel mechanistic pathways and to validate potential new therapeutic interventions prior to pre-clinical testing in humans. Over the past several years, mouse CKD models have been extensively used for these purposes. Despite significant limitations, the model of unilateral ureteral obstruction (UUO) has essentially become the high-throughput in vivo model, as it recapitulates the fundamental pathogenetic mechanisms that typify all forms of CKD in a relatively short time span. In addition, several alternative mouse models are available that can be used to validate new mechanistic paradigms and/or novel therapies. Here, we review several models-both genetic and experimentally induced-that provide investigators with an opportunity to include renal functional study end-points together with quantitative measures of fibrosis severity, something that is not possible with the UUO model." @default.
- W1983456891 created "2016-06-24" @default.
- W1983456891 creator A5001037908 @default.
- W1983456891 creator A5038618758 @default.
- W1983456891 creator A5062110120 @default.
- W1983456891 creator A5065091189 @default.
- W1983456891 date "2011-06-22" @default.
- W1983456891 modified "2023-10-18" @default.
- W1983456891 title "Investigating mechanisms of chronic kidney disease in mouse models" @default.
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