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• W1983457685 abstract "Aim: There is still no specific therapy for infection with the highly pathogenic avian influenza A virus (HPAI) H5N1, which caused 39 human cases with a 64% fatality rate in 2013. Materials & methods: We prepared highly purified specific equine polyclonal immunoglobulin fragments (F(ab’) 2 ) against H5N1 and tested them for efficacy in vitro and with different administration schedules in H5N1-challenged BALB/c mice. Results: in vitro, F(ab’) 2 neutralized 21 different H5N1 strains from different areas, representative of 11 different clades and sub-clades and 9 years of evolution of the virus. In vivo mouse experiments identified that the most efficient administration protocol consists of five consecutive daily injections after infection; 10 mg/kg giving a 60% increase in survival. Conclusion: These data demonstrate the ability of anti-H5N1 F(ab’) 2 to markedly reduce the mortality and morbidity associated with infection of mice with HPAI H5N1 virus, and their potential for human therapy." @default.
• W1983457685 created "2016-06-24" @default.
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• W1983457685 date "2014-06-01" @default.
• W1983457685 modified "2023-09-26" @default.
• W1983457685 title "Specific polyclonal F(ab’)₂ neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice" @default.
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• W1983457685 doi "https://doi.org/10.2217/imt.14.40" @default.
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