FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983461187> ?p ?o ?g. }

• W1983461187 abstract "Depot formulations of antipsychotics provide a potential solution to the poor adherence to oral therapies in schizophrenia. However, there have been few comparative studies on the effectiveness and tolerability of first and second generation depot antipsychotics in a real clinical practice setting. The objectives of the present study were to compare safety and outcomes in patients with schizophrenia initiated on risperidone long-acting injection (RLAI) or first generation antipsychotic injections (FGAI) at a Mental Health Centre in British Columbia. Data were collected by retrospective chart review of all active patients starting depot therapy who were ≥ 18 years of age, had received at least 3 injections of depot antipsychotic and had no prior clozapine treatment. Kaplan Meier survival curves were used to estimate probability of treatment discontinuation and hospitalization. A total of 70 RLAI and 102 FGAI patient charts were reviewed. At baseline patients in both groups had similar ages (39.7 and 42.7 years for RLAI and FGAI patients (p = 0.09), respectively) but FGAI patients had a longer time since diagnosis (13.6 vs. 9.85 years (p = 0.003)). Treatment retention at 18 months was 77% for RLAI and 86% for FGAI patients (p = 0.22) and 82% and 88% of patients, respectively (p = 0.28), had not been hospitalized. However, RLAI analyses were compromised by lack of long-term patient data. Concomitant medication utilization was similar in both groups except for anticholinergics which were used less frequently in RLAI patients (5.7% vs. 35.3%, p < 0.001). Adverse event frequency was also similar except for extrapyramidal symptoms (EPS) which were more common in FGAI patients (52.9% vs. 17.0% for RLAI (p < 0.001)). There was no apparent difference in treatment discontinuation or hospitalization between RLAI and FGAI treated patients, although analysis was compromised by low patient numbers. However, decreased EPS with RLAI may offer a significant clinical benefit to patients with schizophrenia." @default.
• W1983461187 created "2016-06-24" @default.
• W1983461187 creator A5011884418 @default.
• W1983461187 creator A5030464299 @default.
• W1983461187 creator A5068611204 @default.
• W1983461187 date "2013-05-30" @default.
• W1983461187 modified "2023-09-27" @default.
• W1983461187 title "Risperidone long-acting injection in Schizophrenia Spectrum Illnesses compared to first generation depot antipsychotics in an outpatient setting in Canada" @default.
• W1983461187 cites W178879176 @default.
• W1983461187 cites W198284837 @default.
• W1983461187 cites W1999866458 @default.
• W1983461187 cites W2020615571 @default.
• W1983461187 cites W2021838969 @default.
• W1983461187 cites W2047151451 @default.
• W1983461187 cites W2056672347 @default.
• W1983461187 cites W2060417841 @default.
• W1983461187 cites W2078022789 @default.
• W1983461187 cites W2107962758 @default.
• W1983461187 cites W2111694736 @default.
• W1983461187 cites W2112736226 @default.
• W1983461187 cites W2115154429 @default.
• W1983461187 cites W2117578679 @default.
• W1983461187 cites W2132144498 @default.
• W1983461187 cites W2148228045 @default.
• W1983461187 cites W2163962793 @default.
• W1983461187 cites W2165379748 @default.
• W1983461187 cites W2165988750 @default.
• W1983461187 cites W2171958702 @default.
• W1983461187 cites W2196573549 @default.
• W1983461187 cites W4211174138 @default.
• W1983461187 cites W4298076348 @default.
• W1983461187 cites W62870477 @default.
• W1983461187 doi "https://doi.org/10.1186/1471-244x-13-155" @default.
• W1983461187 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3669627" @default.
• W1983461187 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23718192" @default.
• W1983461187 hasPublicationYear "2013" @default.
• W1983461187 type Work @default.
• W1983461187 sameAs 1983461187 @default.
• W1983461187 citedByCount "15" @default.
• W1983461187 countsByYear W19834611872014 @default.
• W1983461187 countsByYear W19834611872015 @default.
• W1983461187 countsByYear W19834611872017 @default.
• W1983461187 countsByYear W19834611872018 @default.
• W1983461187 countsByYear W19834611872019 @default.
• W1983461187 countsByYear W19834611872021 @default.
• W1983461187 countsByYear W19834611872022 @default.
• W1983461187 crossrefType "journal-article" @default.
• W1983461187 hasAuthorship W1983461187A5011884418 @default.
• W1983461187 hasAuthorship W1983461187A5030464299 @default.
• W1983461187 hasAuthorship W1983461187A5068611204 @default.
• W1983461187 hasBestOaLocation W19834611871 @default.
• W1983461187 hasConcept C118552586 @default.
• W1983461187 hasConcept C126322002 @default.
• W1983461187 hasConcept C187212893 @default.
• W1983461187 hasConcept C197934379 @default.
• W1983461187 hasConcept C2776412080 @default.
• W1983461187 hasConcept C2778375690 @default.
• W1983461187 hasConcept C2778715236 @default.
• W1983461187 hasConcept C2779384505 @default.
• W1983461187 hasConcept C2780057945 @default.
• W1983461187 hasConcept C2780494398 @default.
• W1983461187 hasConcept C2780864610 @default.
• W1983461187 hasConcept C71924100 @default.
• W1983461187 hasConceptScore W1983461187C118552586 @default.
• W1983461187 hasConceptScore W1983461187C126322002 @default.
• W1983461187 hasConceptScore W1983461187C187212893 @default.
• W1983461187 hasConceptScore W1983461187C197934379 @default.
• W1983461187 hasConceptScore W1983461187C2776412080 @default.
• W1983461187 hasConceptScore W1983461187C2778375690 @default.
• W1983461187 hasConceptScore W1983461187C2778715236 @default.
• W1983461187 hasConceptScore W1983461187C2779384505 @default.
• W1983461187 hasConceptScore W1983461187C2780057945 @default.
• W1983461187 hasConceptScore W1983461187C2780494398 @default.
• W1983461187 hasConceptScore W1983461187C2780864610 @default.
• W1983461187 hasConceptScore W1983461187C71924100 @default.
• W1983461187 hasIssue "1" @default.
• W1983461187 hasLocation W19834611871 @default.
• W1983461187 hasLocation W19834611872 @default.
• W1983461187 hasLocation W19834611873 @default.
• W1983461187 hasLocation W19834611874 @default.
• W1983461187 hasOpenAccess W1983461187 @default.
• W1983461187 hasPrimaryLocation W19834611871 @default.
• W1983461187 hasRelatedWork W196134381 @default.
• W1983461187 hasRelatedWork W1996291403 @default.
• W1983461187 hasRelatedWork W2097768453 @default.
• W1983461187 hasRelatedWork W2377438392 @default.
• W1983461187 hasRelatedWork W2389739099 @default.
• W1983461187 hasRelatedWork W2792428998 @default.
• W1983461187 hasRelatedWork W3006508639 @default.
• W1983461187 hasRelatedWork W3093992020 @default.
• W1983461187 hasRelatedWork W3173486478 @default.
• W1983461187 hasRelatedWork W4324373046 @default.
• W1983461187 hasVolume "13" @default.
• W1983461187 isParatext "false" @default.
• W1983461187 isRetracted "false" @default.
• W1983461187 magId "1983461187" @default.
• W1983461187 workType "article" @default.