Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983472562> ?p ?o ?g. }
- W1983472562 endingPage "221" @default.
- W1983472562 startingPage "217" @default.
- W1983472562 abstract "The-L system of amino acid transport is markedly diminished in chronic lymphocytic leukemia (CLL) B-lymphocytes, with a maximal velocity less than 15% that of normal B-lymphocytes. Another membrane-associated function, the activity of the ectoenzyme, gamma-glutamyl transpeptidase (GGT), is diminished in CLL B-cells to 30% that of normal B-cells. In addition to its transpeptidase activity, a role for GGT has been postulated in the transport of amino acids. In the present report, the possible relationship of these two physiologic functions in CLL B-cells was studied. The L system transport defect in CLL is restored by phorbol ester-induced cell maturation; following incubation with 0.15 μM tetradecanoyl phorbol acetate (TPA) for 17 hours, the L system initial velocity showed a 20-fold increase. In contrast, there was no significant effect on GGT activity with cell maturation. Furthermore, an antibody which diminished GGT activity by 50% in lymphoid cells did not inhibit L system transport. Thus, the impaired L system amino acid transport and GGT activity appear to be independent processes in CLL B-cells." @default.
- W1983472562 created "2016-06-24" @default.
- W1983472562 creator A5002503870 @default.
- W1983472562 creator A5003552561 @default.
- W1983472562 creator A5004507503 @default.
- W1983472562 creator A5018498818 @default.
- W1983472562 creator A5040118765 @default.
- W1983472562 creator A5061493169 @default.
- W1983472562 creator A5082653656 @default.
- W1983472562 date "1990-11-01" @default.
- W1983472562 modified "2023-09-26" @default.
- W1983472562 title "Decreased L system amino acid transport and decreased gamma-glutamyl transpeptidase are independent processes in human chronic lymphocytic leukemia B-lymphocytes" @default.
- W1983472562 cites W1223981148 @default.
- W1983472562 cites W1483680884 @default.
- W1983472562 cites W1503450484 @default.
- W1983472562 cites W1552195617 @default.
- W1983472562 cites W1555293036 @default.
- W1983472562 cites W1601512140 @default.
- W1983472562 cites W1648994921 @default.
- W1983472562 cites W1970023306 @default.
- W1983472562 cites W1976479314 @default.
- W1983472562 cites W1981319123 @default.
- W1983472562 cites W1981354539 @default.
- W1983472562 cites W1985270173 @default.
- W1983472562 cites W1985322186 @default.
- W1983472562 cites W1996448872 @default.
- W1983472562 cites W2007938003 @default.
- W1983472562 cites W2022516715 @default.
- W1983472562 cites W2059243510 @default.
- W1983472562 cites W2064540741 @default.
- W1983472562 cites W2068309220 @default.
- W1983472562 cites W2071083782 @default.
- W1983472562 cites W2140816566 @default.
- W1983472562 cites W2415460162 @default.
- W1983472562 cites W30889147 @default.
- W1983472562 doi "https://doi.org/10.1002/jcp.1041450205" @default.
- W1983472562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1978835" @default.
- W1983472562 hasPublicationYear "1990" @default.
- W1983472562 type Work @default.
- W1983472562 sameAs 1983472562 @default.
- W1983472562 citedByCount "12" @default.
- W1983472562 countsByYear W19834725622012 @default.
- W1983472562 countsByYear W19834725622014 @default.
- W1983472562 countsByYear W19834725622017 @default.
- W1983472562 countsByYear W19834725622018 @default.
- W1983472562 countsByYear W19834725622020 @default.
- W1983472562 crossrefType "journal-article" @default.
- W1983472562 hasAuthorship W1983472562A5002503870 @default.
- W1983472562 hasAuthorship W1983472562A5003552561 @default.
- W1983472562 hasAuthorship W1983472562A5004507503 @default.
- W1983472562 hasAuthorship W1983472562A5018498818 @default.
- W1983472562 hasAuthorship W1983472562A5040118765 @default.
- W1983472562 hasAuthorship W1983472562A5061493169 @default.
- W1983472562 hasAuthorship W1983472562A5082653656 @default.
- W1983472562 hasConcept C126322002 @default.
- W1983472562 hasConcept C134018914 @default.
- W1983472562 hasConcept C153911025 @default.
- W1983472562 hasConcept C181199279 @default.
- W1983472562 hasConcept C185592680 @default.
- W1983472562 hasConcept C195794163 @default.
- W1983472562 hasConcept C203014093 @default.
- W1983472562 hasConcept C25642318 @default.
- W1983472562 hasConcept C2777938653 @default.
- W1983472562 hasConcept C2778461978 @default.
- W1983472562 hasConcept C2780043322 @default.
- W1983472562 hasConcept C515207424 @default.
- W1983472562 hasConcept C55493867 @default.
- W1983472562 hasConcept C71924100 @default.
- W1983472562 hasConcept C86803240 @default.
- W1983472562 hasConceptScore W1983472562C126322002 @default.
- W1983472562 hasConceptScore W1983472562C134018914 @default.
- W1983472562 hasConceptScore W1983472562C153911025 @default.
- W1983472562 hasConceptScore W1983472562C181199279 @default.
- W1983472562 hasConceptScore W1983472562C185592680 @default.
- W1983472562 hasConceptScore W1983472562C195794163 @default.
- W1983472562 hasConceptScore W1983472562C203014093 @default.
- W1983472562 hasConceptScore W1983472562C25642318 @default.
- W1983472562 hasConceptScore W1983472562C2777938653 @default.
- W1983472562 hasConceptScore W1983472562C2778461978 @default.
- W1983472562 hasConceptScore W1983472562C2780043322 @default.
- W1983472562 hasConceptScore W1983472562C515207424 @default.
- W1983472562 hasConceptScore W1983472562C55493867 @default.
- W1983472562 hasConceptScore W1983472562C71924100 @default.
- W1983472562 hasConceptScore W1983472562C86803240 @default.
- W1983472562 hasIssue "2" @default.
- W1983472562 hasLocation W19834725621 @default.
- W1983472562 hasLocation W19834725622 @default.
- W1983472562 hasOpenAccess W1983472562 @default.
- W1983472562 hasPrimaryLocation W19834725621 @default.
- W1983472562 hasRelatedWork W1644178486 @default.
- W1983472562 hasRelatedWork W1956062754 @default.
- W1983472562 hasRelatedWork W2004312381 @default.
- W1983472562 hasRelatedWork W2054038633 @default.
- W1983472562 hasRelatedWork W2070211997 @default.
- W1983472562 hasRelatedWork W2100264247 @default.
- W1983472562 hasRelatedWork W2141504910 @default.
- W1983472562 hasRelatedWork W2171787368 @default.
- W1983472562 hasRelatedWork W2212096471 @default.