FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983498247> ?p ?o ?g. }

• W1983498247 endingPage "662" @default.
• W1983498247 startingPage "653" @default.
• W1983498247 abstract "Despite successful therapies for chronic hypertension, hospital admissions for hypertensive emergency more than tripled between 1983 and 1992.To examine the safety and efficacy of fenoldopam, the first antihypertensive with selective and specific action on vascular dopamine (DA1) receptors, in a clinical trial involving emergency department patients with true hypertensive emergencies.Patients with a sustained diastolic blood pressure (DBP) of > or =120 mm Hg and evidence of target organ compromise were randomized in a double-blinded manner to one of four fixed doses of intravenous fenoldopam (0.01, 0.03, 0.1, or 0.3 microg/kg/min) for 24 hours. The primary endpoint was the magnitude of DBP reduction in each of the three higher-dose groups after four hours of fenoldopam treatment compared with the lowest-dose group.One hundred seven participants from 21 centers were enrolled, and 94 patients received fenoldopam. Evidence of acute target-organ damage included new renal dysfunction or hematuria (50%), acute congestive heart failure or myocardial ischemia (48%), and papilledema or grade III-IV hypertensive retinopathy (34%). The DBP decreased in a dose-dependent fashion, with significant differences between the 0.1- and 0.3-microg/kg/min groups compared with the lowest-dose group. Treatment was well tolerated, and there were no deaths or serious adverse events during follow-up, up to 48 hours. All patients were successfully transitioned to oral or transdermal antihypertensives with maintenance of blood pressure control.Fenoldopam safely and effectively lowers blood pressure in a dose-dependent manner in patients with hypertensive emergencies. Observations supporting potential risk factors for hypertensive emergency are discussed." @default.
• W1983498247 created "2016-06-24" @default.
• W1983498247 creator A5002246155 @default.
• W1983498247 creator A5002876363 @default.
• W1983498247 creator A5017120025 @default.
• W1983498247 creator A5022608652 @default.
• W1983498247 creator A5023188102 @default.
• W1983498247 creator A5042912585 @default.
• W1983498247 creator A5050998034 @default.
• W1983498247 creator A5058965585 @default.
• W1983498247 creator A5078385927 @default.
• W1983498247 creator A5080584791 @default.
• W1983498247 date "2008-06-28" @default.
• W1983498247 modified "2023-10-17" @default.
• W1983498247 title "Fenoldopam, a Dopamine Agonist, for Hypertensive Emergency: A Multicenter Randomized Trial" @default.
• W1983498247 cites W1971666673 @default.
• W1983498247 cites W1975838486 @default.
• W1983498247 cites W1992012747 @default.
• W1983498247 cites W1993836870 @default.
• W1983498247 cites W1996654846 @default.
• W1983498247 cites W2007380876 @default.
• W1983498247 cites W2008548381 @default.
• W1983498247 cites W2008733532 @default.
• W1983498247 cites W2008885520 @default.
• W1983498247 cites W2027768749 @default.
• W1983498247 cites W2042103167 @default.
• W1983498247 cites W2048018329 @default.
• W1983498247 cites W2066561869 @default.
• W1983498247 cites W2079069842 @default.
• W1983498247 cites W2081108216 @default.
• W1983498247 cites W2086149729 @default.
• W1983498247 cites W2117107809 @default.
• W1983498247 cites W2129830268 @default.
• W1983498247 cites W2134462651 @default.
• W1983498247 cites W2314684066 @default.
• W1983498247 cites W2402052113 @default.
• W1983498247 cites W4255594164 @default.
• W1983498247 cites W4298022342 @default.
• W1983498247 doi "https://doi.org/10.1111/j.1553-2712.2000.tb02039.x" @default.
• W1983498247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10905644" @default.
• W1983498247 hasPublicationYear "2008" @default.
• W1983498247 type Work @default.
• W1983498247 sameAs 1983498247 @default.
• W1983498247 citedByCount "71" @default.
• W1983498247 countsByYear W19834982472012 @default.
• W1983498247 countsByYear W19834982472013 @default.
• W1983498247 countsByYear W19834982472014 @default.
• W1983498247 countsByYear W19834982472015 @default.
• W1983498247 countsByYear W19834982472016 @default.
• W1983498247 countsByYear W19834982472017 @default.
• W1983498247 countsByYear W19834982472019 @default.
• W1983498247 countsByYear W19834982472020 @default.
• W1983498247 countsByYear W19834982472021 @default.
• W1983498247 countsByYear W19834982472022 @default.
• W1983498247 countsByYear W19834982472023 @default.
• W1983498247 crossrefType "journal-article" @default.
• W1983498247 hasAuthorship W1983498247A5002246155 @default.
• W1983498247 hasAuthorship W1983498247A5002876363 @default.
• W1983498247 hasAuthorship W1983498247A5017120025 @default.
• W1983498247 hasAuthorship W1983498247A5022608652 @default.
• W1983498247 hasAuthorship W1983498247A5023188102 @default.
• W1983498247 hasAuthorship W1983498247A5042912585 @default.
• W1983498247 hasAuthorship W1983498247A5050998034 @default.
• W1983498247 hasAuthorship W1983498247A5058965585 @default.
• W1983498247 hasAuthorship W1983498247A5078385927 @default.
• W1983498247 hasAuthorship W1983498247A5080584791 @default.
• W1983498247 hasBestOaLocation W19834982471 @default.
• W1983498247 hasConcept C126322002 @default.
• W1983498247 hasConcept C170493617 @default.
• W1983498247 hasConcept C197934379 @default.
• W1983498247 hasConcept C2776385636 @default.
• W1983498247 hasConcept C2778938600 @default.
• W1983498247 hasConcept C2779867896 @default.
• W1983498247 hasConcept C42219234 @default.
• W1983498247 hasConcept C71924100 @default.
• W1983498247 hasConcept C84393581 @default.
• W1983498247 hasConceptScore W1983498247C126322002 @default.
• W1983498247 hasConceptScore W1983498247C170493617 @default.
• W1983498247 hasConceptScore W1983498247C197934379 @default.
• W1983498247 hasConceptScore W1983498247C2776385636 @default.
• W1983498247 hasConceptScore W1983498247C2778938600 @default.
• W1983498247 hasConceptScore W1983498247C2779867896 @default.
• W1983498247 hasConceptScore W1983498247C42219234 @default.
• W1983498247 hasConceptScore W1983498247C71924100 @default.
• W1983498247 hasConceptScore W1983498247C84393581 @default.
• W1983498247 hasIssue "6" @default.
• W1983498247 hasLocation W19834982471 @default.
• W1983498247 hasLocation W19834982472 @default.
• W1983498247 hasOpenAccess W1983498247 @default.
• W1983498247 hasPrimaryLocation W19834982471 @default.
• W1983498247 hasRelatedWork W1592571261 @default.
• W1983498247 hasRelatedWork W2039055907 @default.
• W1983498247 hasRelatedWork W2052049897 @default.
• W1983498247 hasRelatedWork W2058541924 @default.
• W1983498247 hasRelatedWork W2111216488 @default.
• W1983498247 hasRelatedWork W2143965847 @default.
• W1983498247 hasRelatedWork W2167854849 @default.
• W1983498247 hasRelatedWork W2196520861 @default.

• next