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- W1983507978 abstract "The effects have been studied of Pluronic® F-68 at 0.04% (w/v) on platelet aggregation in hirudin (50 μ ml-1)-anticoagulated, human whole blood in vitro in response to the following aggregation agonists: (i) phorbol 12-myristate 13-acetate (PMA; 0.05, 0.1 or 0.15 μg ml-1), (ii) collagen (0.125, 0.25 or 0.5 μg ml-1), or (iii) ristocetin (0.3, 0.6 or 1.2 μg m 1-1). Pluronic® F-68 significantly (P<0.05) inhibited platelet aggregation that followed the addition of all agonists at their lowest concentration tested. Pluronic F-68 had markedly less pronounced inhibitory effects on the platelet aggregation that occurred in response to 0.15 μg ml-1 PMA, where the mean % aggregation after 8 min was 67% of control (P<0.05). Pluronic® F-68 did not alter platelet aggregation in blood treated with 0.25 or 0.5 μg ml-1' of collagen." @default.
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- W1983507978 date "1998-01-01" @default.
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- W1983507978 title "Pluronid® F-68 Inhibits Agonist-Induced Platelet Aggregation in Human Whole Blood in Vitro" @default.
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- W1983507978 doi "https://doi.org/10.3109/10731199809117464" @default.
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