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- W1983509869 abstract "By conducting a structure-activity relationship study of the backbone of a series of oligoamide-foldamer-based α-helix mimetics of the Bak BH3 helix, we have identified especially potent inhibitors of Bcl-x(L). The most potent compound has a K(i) value of 94 nM in vitro, and single-digit micromolar IC(50) values against the proliferation of several Bcl-x(L)-overexpressing cancer cell lines." @default.
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- W1983509869 date "2012-01-01" @default.
- W1983509869 modified "2023-09-27" @default.
- W1983509869 title "Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors" @default.
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- W1983509869 doi "https://doi.org/10.1039/c2ob07125h" @default.
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