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- W1983509957 abstract "Given the rapid rate of population aging and the increased incidence of cognitive decline and neurodegenerative diseases with advanced age, it is important to ascertain the determinants that result in cognitive impairment. It is also important to note that much of the aged population exhibit ‘successful’ cognitive aging, in which cognitive impairment is minimal. One main goal of normal aging studies is to distinguish the neural changes that occur in unsuccessful (functionally impaired) subjects from those of successful (functionally unimpaired) subjects. In this review, we present some of the structural adaptations that neurons and spines undergo throughout normal aging and discuss their likely contributions to electrophysiological properties and cognition. Structural changes of neurons and dendritic spines during aging, and the functional consequences of such changes, remain poorly understood. Elucidating the structural and functional synaptic age-related changes that lead to cognitive impairment may lead to the development of drug treatments that can restore or protect neural circuits and mediate cognition and successful aging." @default.
- W1983509957 created "2016-06-24" @default.
- W1983509957 creator A5033400620 @default.
- W1983509957 creator A5059938010 @default.
- W1983509957 creator A5073037534 @default.
- W1983509957 creator A5074358590 @default.
- W1983509957 date "2013-10-01" @default.
- W1983509957 modified "2023-10-03" @default.
- W1983509957 title "Dendritic spine changes associated with normal aging" @default.
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