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• W1983537891 abstract "Presentation of milk to the newborn rat promotes changes in sensory and motor behavior and concomitant changes in both endogenous opioid and dopamine systems. The present study employed an in vivo binding technique with a tritiated ligand for the D2 receptor ([3H]raclopride) to examine the effects of intraoral milk infusion and opioid manipulations on dopamine activity in the term rat fetus (E21). In Experiment 1, fetuses received a series of milk infusion, which resulted in decreased occupancy at D2 receptors by the endogenous ligand, dopamine, in striatal, septal, and hypothalamic brain regions. In Experiment 2, fetuses were pretreated with morphine, the mu-agonist [D-Ala2,NMe-Phe4,Gly5-ol]-enkephalin (DAMGO), the kappa-agonist U50,488, or saline. Opioid manipulations had no effect on binding at D2 receptors. These results confirm that intraoral milk infusion can modulate activity in the dopamine system of the near-term fetal rat." @default.
• W1983537891 created "2016-06-24" @default.
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• W1983537891 date "1993-10-01" @default.
• W1983537891 modified "2023-10-18" @default.
• W1983537891 title "Modulation of dopamine binding in the fetal rat: Effects of milk and exogenous opioid manipulation" @default.
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• W1983537891 doi "https://doi.org/10.1016/0091-3057(93)90367-3" @default.
• W1983537891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8265693" @default.
• W1983537891 hasPublicationYear "1993" @default.
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