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- W1983542898 abstract "Current theories of affective disorders do not account for many of the biological markers replicated in patient studies. We link many biological findings in a reasonable physiological relationship, compatible with mechanisms of action of pharmacological and electroshock therapies for depression. We propose that excessive phospholipase-A2 (PLA2) activity disrupts membrane fluidity, composition, and therefore, the activity, of membranedependent proteins. Similar disruptions in these proteins are documented in depressed patients and can be accounted for by excessive PLA2 activity. This paradigm accounts for disturbances in the activity of Na-K-ATPase, beta2- and alpha2-adrenergic receptors, MAO, norepinephrine and serotonin uptake, and imipramine binding. Disturbances in other membrane-dependent proteins, tyrosine and tryptophan hydroxylase, can explain the biogenic amine hypothesis. Inhibition of glucocorticoid receptor and TRH receptor binding to their respective ligands by PLA2 may explain patient nonsuppression in the Dexamethasone Suppression Test and poor response in the TRH stimulation test. Physiological regulators of PLA2 activity; calcium, cortisol, estrogen, progesterone, andPGE2 are documented abnormalities in some patients with affective disorders and consistent with excessive PLA2 activity. Thus, postpartum depression and premenstrual tension syndrome may be described in the paradigm. The mechanisms of action of tricyclic antidepressants, lithium, electroconvulsive shock, and some novel antimanic agents can be described in terms of alterations of PLA2 activity. Interestingly, ethanol perturbs membrane fluidity and membrane-bound enzymes in a manner similar to excessive PLA2 activity. A hereditary factor predisposing patients to affective disorders may be a gene defect at either PLA2 or in its regulation." @default.
- W1983542898 created "2016-06-24" @default.
- W1983542898 creator A5001748130 @default.
- W1983542898 creator A5033693439 @default.
- W1983542898 creator A5052026137 @default.
- W1983542898 date "1989-04-01" @default.
- W1983542898 modified "2023-10-01" @default.
- W1983542898 title "Are disturbances in lipid-protein interactions by phospholipase-A2 a predisposing factor in affective illness?" @default.
- W1983542898 cites W100889661 @default.
- W1983542898 cites W13275948 @default.
- W1983542898 cites W1530854705 @default.
- W1983542898 cites W1552704019 @default.
- W1983542898 cites W1577386719 @default.
- W1983542898 cites W1585539177 @default.
- W1983542898 cites W1758121263 @default.
- W1983542898 cites W1879047861 @default.
- W1983542898 cites W1889236699 @default.
- W1983542898 cites W1919360935 @default.
- W1983542898 cites W1927894522 @default.
- W1983542898 cites W1968858148 @default.
- W1983542898 cites W1969010931 @default.
- W1983542898 cites W1971162866 @default.
- W1983542898 cites W1971705822 @default.
- W1983542898 cites W1972961916 @default.
- W1983542898 cites W1975686097 @default.
- W1983542898 cites W1976657983 @default.
- W1983542898 cites W1977821685 @default.
- W1983542898 cites W1978493685 @default.
- W1983542898 cites W1980237253 @default.
- W1983542898 cites W1982064767 @default.
- W1983542898 cites W1984656110 @default.
- W1983542898 cites W1984775580 @default.
- W1983542898 cites W1990187515 @default.
- W1983542898 cites W1993826259 @default.
- W1983542898 cites W1995561716 @default.
- W1983542898 cites W1995782272 @default.
- W1983542898 cites W2002121296 @default.
- W1983542898 cites W2002457546 @default.
- W1983542898 cites W2004535855 @default.
- W1983542898 cites W2008403940 @default.
- W1983542898 cites W2010251178 @default.
- W1983542898 cites W2011296485 @default.
- W1983542898 cites W2011479344 @default.
- W1983542898 cites W2011561455 @default.
- W1983542898 cites W2011612262 @default.
- W1983542898 cites W2013191360 @default.
- W1983542898 cites W2014872690 @default.
- W1983542898 cites W2016681617 @default.
- W1983542898 cites W2022695672 @default.
- W1983542898 cites W2022770606 @default.
- W1983542898 cites W2022887312 @default.
- W1983542898 cites W2024304749 @default.
- W1983542898 cites W2027913921 @default.
- W1983542898 cites W2028180466 @default.
- W1983542898 cites W2030838046 @default.
- W1983542898 cites W2033324585 @default.
- W1983542898 cites W2037559510 @default.
- W1983542898 cites W2039535895 @default.
- W1983542898 cites W2040535793 @default.
- W1983542898 cites W2040554478 @default.
- W1983542898 cites W2044058025 @default.
- W1983542898 cites W2045599452 @default.
- W1983542898 cites W2045680787 @default.
- W1983542898 cites W2046482251 @default.
- W1983542898 cites W2047534694 @default.
- W1983542898 cites W2050370232 @default.
- W1983542898 cites W2052570973 @default.
- W1983542898 cites W2054023462 @default.
- W1983542898 cites W2054155132 @default.
- W1983542898 cites W2058282000 @default.
- W1983542898 cites W2059963986 @default.
- W1983542898 cites W2060771044 @default.
- W1983542898 cites W2061158659 @default.
- W1983542898 cites W2063089249 @default.
- W1983542898 cites W2064412257 @default.
- W1983542898 cites W2072116455 @default.
- W1983542898 cites W2072219714 @default.
- W1983542898 cites W2073528212 @default.
- W1983542898 cites W2080013813 @default.
- W1983542898 cites W2080160557 @default.
- W1983542898 cites W2085337357 @default.
- W1983542898 cites W2086437482 @default.
- W1983542898 cites W2087421641 @default.
- W1983542898 cites W2090204883 @default.
- W1983542898 cites W2090787320 @default.
- W1983542898 cites W2091279462 @default.
- W1983542898 cites W2091522575 @default.
- W1983542898 cites W2094206611 @default.
- W1983542898 cites W2096596152 @default.
- W1983542898 cites W2103158344 @default.
- W1983542898 cites W2105224505 @default.
- W1983542898 cites W2107326323 @default.
- W1983542898 cites W2116547841 @default.
- W1983542898 cites W2123979863 @default.
- W1983542898 cites W2125505240 @default.
- W1983542898 cites W2132757457 @default.
- W1983542898 cites W2139127386 @default.
- W1983542898 cites W2144001258 @default.