FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983549722> ?p ?o ?g. }

• W1983549722 endingPage "10" @default.
• W1983549722 startingPage "1" @default.
• W1983549722 abstract "Cells from yeast to humans activate unconventional mRNA splicing when unfolded proteins accumulate in the endoplasmic reticulum (ER) under ER stress conditions. The substrate of this splicing in mammalian cells is XBP1 mRNA, which encodes the unfolded protein response (UPR)-specific transcription factor XBP1. The C-terminal region of XBP1 is switched as a result of the splicing. Thus, unspliced and spliced mRNAs produce pXBP1(U) of 261 aa and pXBP1(S) of 376 aa, respectively, with the N-terminal region containing the DNA-binding domain shared. As the pXBP1(S)-specific C-terminal region functions as an activation domain, pXBP1(S) can activate transcription efficiently. We recently found that pXBP1(U) shuttles between the nucleus and cytoplasm, owing to the presence of a nuclear exclusion signal in the pXBP1(U)-specific C-terminal region, in marked contrast to the exclusively nuclear localization of pXBP1(S). pXBP1(U) can associate with pXBP1(S), and pXBP1(U)-pXBP1(S) complex is rapidly degraded by the proteasome. Two other transcription factors are activated in response to ER stress, namely ATF6 and ATF4. ATF6 is a UPR-specific transcription factor, whereas ATF4 is activated by not only ER stress but also various other stimuli. In this study, we show that pXBP1(U) targets the active form of ATF6 but not ATF4 for destruction by the proteasome via direct association. This enhanced degradation is mediated by the degradation domain located at the pXBP1(U)-specific C-terminal end. We conclude that pXBP1(U) functions as a negative regulator of the UPR-specific transcription factors ATF6 and pXBP1(S)." @default.
• W1983549722 created "2016-06-24" @default.
• W1983549722 creator A5000228938 @default.
• W1983549722 creator A5024825620 @default.
• W1983549722 creator A5060319133 @default.
• W1983549722 date "2009-01-01" @default.
• W1983549722 modified "2023-10-17" @default.
• W1983549722 title "pXBP1(U), a Negative Regulator of the Unfolded Protein Response Activator pXBP1(S), Targets ATF6 but not ATF4 in Proteasome-mediated Degradation" @default.
• W1983549722 cites W1832137879 @default.
• W1983549722 cites W1970090817 @default.
• W1983549722 cites W1986737010 @default.
• W1983549722 cites W1991770908 @default.
• W1983549722 cites W2019192392 @default.
• W1983549722 cites W2019424220 @default.
• W1983549722 cites W2021028081 @default.
• W1983549722 cites W2029642537 @default.
• W1983549722 cites W2031735388 @default.
• W1983549722 cites W2036677133 @default.
• W1983549722 cites W2047498253 @default.
• W1983549722 cites W2053470799 @default.
• W1983549722 cites W2054631447 @default.
• W1983549722 cites W2055836716 @default.
• W1983549722 cites W2071273959 @default.
• W1983549722 cites W2071974979 @default.
• W1983549722 cites W2083445344 @default.
• W1983549722 cites W2088510522 @default.
• W1983549722 cites W2100472948 @default.
• W1983549722 cites W2112286580 @default.
• W1983549722 cites W2115137627 @default.
• W1983549722 cites W2121576917 @default.
• W1983549722 cites W2127639686 @default.
• W1983549722 cites W2127848114 @default.
• W1983549722 cites W2127906377 @default.
• W1983549722 cites W2131632095 @default.
• W1983549722 cites W2144065739 @default.
• W1983549722 cites W2144983282 @default.
• W1983549722 cites W2162076197 @default.
• W1983549722 cites W2164783065 @default.
• W1983549722 cites W4255593825 @default.
• W1983549722 doi "https://doi.org/10.1247/csf.06028" @default.
• W1983549722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19122331" @default.
• W1983549722 hasPublicationYear "2009" @default.
• W1983549722 type Work @default.
• W1983549722 sameAs 1983549722 @default.
• W1983549722 citedByCount "95" @default.
• W1983549722 countsByYear W19835497222012 @default.
• W1983549722 countsByYear W19835497222013 @default.
• W1983549722 countsByYear W19835497222014 @default.
• W1983549722 countsByYear W19835497222015 @default.
• W1983549722 countsByYear W19835497222016 @default.
• W1983549722 countsByYear W19835497222017 @default.
• W1983549722 countsByYear W19835497222018 @default.
• W1983549722 countsByYear W19835497222019 @default.
• W1983549722 countsByYear W19835497222020 @default.
• W1983549722 countsByYear W19835497222021 @default.
• W1983549722 countsByYear W19835497222022 @default.
• W1983549722 countsByYear W19835497222023 @default.
• W1983549722 crossrefType "journal-article" @default.
• W1983549722 hasAuthorship W1983549722A5000228938 @default.
• W1983549722 hasAuthorship W1983549722A5024825620 @default.
• W1983549722 hasAuthorship W1983549722A5060319133 @default.
• W1983549722 hasBestOaLocation W19835497221 @default.
• W1983549722 hasConcept C104317684 @default.
• W1983549722 hasConcept C139447449 @default.
• W1983549722 hasConcept C153911025 @default.
• W1983549722 hasConcept C158617107 @default.
• W1983549722 hasConcept C185592680 @default.
• W1983549722 hasConcept C27740335 @default.
• W1983549722 hasConcept C2778997996 @default.
• W1983549722 hasConcept C2780900454 @default.
• W1983549722 hasConcept C2781331208 @default.
• W1983549722 hasConcept C2992195973 @default.
• W1983549722 hasConcept C54458228 @default.
• W1983549722 hasConcept C55493867 @default.
• W1983549722 hasConcept C67705224 @default.
• W1983549722 hasConcept C86339819 @default.
• W1983549722 hasConcept C86803240 @default.
• W1983549722 hasConcept C95444343 @default.
• W1983549722 hasConceptScore W1983549722C104317684 @default.
• W1983549722 hasConceptScore W1983549722C139447449 @default.
• W1983549722 hasConceptScore W1983549722C153911025 @default.
• W1983549722 hasConceptScore W1983549722C158617107 @default.
• W1983549722 hasConceptScore W1983549722C185592680 @default.
• W1983549722 hasConceptScore W1983549722C27740335 @default.
• W1983549722 hasConceptScore W1983549722C2778997996 @default.
• W1983549722 hasConceptScore W1983549722C2780900454 @default.
• W1983549722 hasConceptScore W1983549722C2781331208 @default.
• W1983549722 hasConceptScore W1983549722C2992195973 @default.
• W1983549722 hasConceptScore W1983549722C54458228 @default.
• W1983549722 hasConceptScore W1983549722C55493867 @default.
• W1983549722 hasConceptScore W1983549722C67705224 @default.
• W1983549722 hasConceptScore W1983549722C86339819 @default.
• W1983549722 hasConceptScore W1983549722C86803240 @default.
• W1983549722 hasConceptScore W1983549722C95444343 @default.
• W1983549722 hasIssue "1" @default.
• W1983549722 hasLocation W19835497221 @default.
• W1983549722 hasLocation W19835497222 @default.
• W1983549722 hasOpenAccess W1983549722 @default.

• next