Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983553061> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1983553061 endingPage "356" @default.
- W1983553061 startingPage "345" @default.
- W1983553061 abstract "Defects in DNA damage response and repair mechanism increase instability and predispose to cancer. Critical roles in the maintenance of stability play TP53 and BRCA1/2 genes, inherited germline mutations of which predispose to breast and ovarian cancers. BRCA1/2 are a breast tumor susceptibility factors with functions in maintaining stability through ensuring efficient double-strand DNA break (DSB) repair by homologous recombination. p53 protein known as a guardian of the genome is involved in maintenance of genomic integrity by several major DNA damage response mechanisms including cell cycle arrest, DNA repair or induction of apoptosis when damage is excessive. By a role in preserving genomic integrity, BRCA1, BRCA2 and p53 belong to the most thoroughly analyzed human proteins. Surprisingly, BRCA1 as well as BRCA2 homologs are also present in higher plants. The homology between human BRCA genes and their plant homologs is mainly conserved in the region of their functional domains. To date, functions of plant BRCA-like genes have only been studied for Arabidopsis thaliana. In the Arabidopsis two BRCA2-like genes (AtBRCA2) were found. Their products are essential for DSB repair in somatic cells and have a role in meiotic recombination. In the absence of functional AtBRCA2, plants were sterile owing to a failure to repair meiotic DSBs and chromosomal instability. Genetic studies of one Arabidopsis BRCA1-like gene (AtBRCA1) have shown their involvement in cell-cycle control and DNA repair. Arabidopsis mutant plants defective for the AtBRCA1 or BRCA2 are sensitive to DNA cross-linking reagents, such as mitomycin C, and to DSB inducing treatments, such as exposure to the radiomimetic bleomycin. Taken together, these studies provided the first physiological evidence that BRCA genes functions were conserved in plants. In contrast to BRCA genes, homolog of the p53 protein has not yet been identified in plants, suggesting that, if a p53 plant gene exists, it might share little sequence homology with its human counterpart." @default.
- W1983553061 created "2016-06-24" @default.
- W1983553061 creator A5063802433 @default.
- W1983553061 creator A5080341246 @default.
- W1983553061 date "2011-01-01" @default.
- W1983553061 modified "2023-09-25" @default.
- W1983553061 title "Roślinne homologii genów związanych z dziedziczną predyspozycją do raka piersi i jajnika" @default.
- W1983553061 cites W1444557035 @default.
- W1983553061 cites W1978546008 @default.
- W1983553061 cites W1981191944 @default.
- W1983553061 cites W2000511377 @default.
- W1983553061 cites W2001124416 @default.
- W1983553061 cites W2010457192 @default.
- W1983553061 cites W2019205168 @default.
- W1983553061 cites W2019364309 @default.
- W1983553061 cites W2023491752 @default.
- W1983553061 cites W2025955579 @default.
- W1983553061 cites W2034146467 @default.
- W1983553061 cites W2034269086 @default.
- W1983553061 cites W2042637377 @default.
- W1983553061 cites W2060972565 @default.
- W1983553061 cites W2066969492 @default.
- W1983553061 cites W2067993067 @default.
- W1983553061 cites W2070373522 @default.
- W1983553061 cites W2070682842 @default.
- W1983553061 cites W2091350790 @default.
- W1983553061 cites W2093022435 @default.
- W1983553061 cites W2102976776 @default.
- W1983553061 cites W2110143497 @default.
- W1983553061 cites W2127528448 @default.
- W1983553061 cites W2130238339 @default.
- W1983553061 cites W2143607835 @default.
- W1983553061 cites W2143980861 @default.
- W1983553061 cites W2147100149 @default.
- W1983553061 cites W2155227318 @default.
- W1983553061 cites W2161441477 @default.
- W1983553061 cites W2171917686 @default.
- W1983553061 cites W2414466603 @default.
- W1983553061 cites W3169642225 @default.
- W1983553061 cites W809601934 @default.
- W1983553061 cites W1539805263 @default.
- W1983553061 hasPublicationYear "2011" @default.
- W1983553061 type Work @default.
- W1983553061 sameAs 1983553061 @default.
- W1983553061 citedByCount "0" @default.
- W1983553061 crossrefType "journal-article" @default.
- W1983553061 hasAuthorship W1983553061A5063802433 @default.
- W1983553061 hasAuthorship W1983553061A5080341246 @default.
- W1983553061 hasConcept C102744134 @default.
- W1983553061 hasConcept C104317684 @default.
- W1983553061 hasConcept C134935766 @default.
- W1983553061 hasConcept C143065580 @default.
- W1983553061 hasConcept C143425029 @default.
- W1983553061 hasConcept C178169997 @default.
- W1983553061 hasConcept C2779491563 @default.
- W1983553061 hasConcept C54355233 @default.
- W1983553061 hasConcept C552990157 @default.
- W1983553061 hasConcept C86803240 @default.
- W1983553061 hasConcept C95444343 @default.
- W1983553061 hasConceptScore W1983553061C102744134 @default.
- W1983553061 hasConceptScore W1983553061C104317684 @default.
- W1983553061 hasConceptScore W1983553061C134935766 @default.
- W1983553061 hasConceptScore W1983553061C143065580 @default.
- W1983553061 hasConceptScore W1983553061C143425029 @default.
- W1983553061 hasConceptScore W1983553061C178169997 @default.
- W1983553061 hasConceptScore W1983553061C2779491563 @default.
- W1983553061 hasConceptScore W1983553061C54355233 @default.
- W1983553061 hasConceptScore W1983553061C552990157 @default.
- W1983553061 hasConceptScore W1983553061C86803240 @default.
- W1983553061 hasConceptScore W1983553061C95444343 @default.
- W1983553061 hasLocation W19835530611 @default.
- W1983553061 hasOpenAccess W1983553061 @default.
- W1983553061 hasPrimaryLocation W19835530611 @default.
- W1983553061 hasVolume "60" @default.
- W1983553061 isParatext "false" @default.
- W1983553061 isRetracted "false" @default.
- W1983553061 magId "1983553061" @default.
- W1983553061 workType "article" @default.