FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983557750> ?p ?o ?g. }

• W1983557750 endingPage "342" @default.
• W1983557750 startingPage "333" @default.
• W1983557750 abstract "Intestinal epithelial cells are the initial sites of host response to Clostridium difficile infection and can play a role in signaling the influx of inflammatory cells. To further explore this role, the regulated expression and polarized secretion of CXC and CC chemokines by human intestinal epithelial cells were investigated. An expression of the CXC chemokines, including IL-8 and growth-related oncogene (GRO)-alpha, and the CC chemokine monocyte chemoattractant protein (MCP)-1 from HT-29 cells increased in the 1-6 hr following C. difficile toxin A stimulation, assessed by quantitative RT-PCR. In contrast, the expression of neutrophil activating protein-78 (ENA-78) was delayed for 18 hr. The up-regulated mRNA expression of chemokines was paralleled by the increase of protein levels. However, the expression of macrophage inflammatory protein (MIP)-1alpha, RANTES (regulated on activation normal T cells expressed and secreted), and interferon-gamma-inducible protein-10 (IP-10) was not changed in HT-29 or Caco-2 cells stimulated with toxin A. Upon stimulation of the polarized Caco-2 epithelial cells in a transwell chamber with toxin A, CXC and CC chemokines were released predominantly into the basolateral compartment. Moreover, the addition of IFN-gamma and TNF-alpha to toxin A stimulated Caco-2 cells increased the basolateral release of CC chemokine MCP-1. In contrast, IFN-gamma and TNF-alpha had no effect on the expression of the CXC chemokines IL-8 and GRO-alpha. These results suggest that a CXC and CC chemokine expression from epithelial cells infected with C. difficile may be an important factor in the mucosal inflammatory response." @default.
• W1983557750 created "2016-06-24" @default.
• W1983557750 creator A5014332786 @default.
• W1983557750 creator A5020772809 @default.
• W1983557750 creator A5043856063 @default.
• W1983557750 creator A5047347247 @default.
• W1983557750 creator A5051420590 @default.
• W1983557750 creator A5084473082 @default.
• W1983557750 date "2002-05-01" @default.
• W1983557750 modified "2023-09-24" @default.
• W1983557750 title "Differential Expression and Polarized Secretion of CXC and CC Chemokines by Human Intestinal Epithelial Cancer Cell Lines in Response to<i>Clostridium difficile</i>Toxin A" @default.
• W1983557750 cites W1489558910 @default.
• W1983557750 cites W1497553226 @default.
• W1983557750 cites W1973874784 @default.
• W1983557750 cites W2006219739 @default.
• W1983557750 cites W2010259603 @default.
• W1983557750 cites W2011843272 @default.
• W1983557750 cites W2013594928 @default.
• W1983557750 cites W2018977639 @default.
• W1983557750 cites W2041278570 @default.
• W1983557750 cites W2042371095 @default.
• W1983557750 cites W2052887693 @default.
• W1983557750 cites W2055144655 @default.
• W1983557750 cites W2058235525 @default.
• W1983557750 cites W2069800046 @default.
• W1983557750 cites W2079968415 @default.
• W1983557750 cites W2086050882 @default.
• W1983557750 cites W2088186083 @default.
• W1983557750 cites W2090079961 @default.
• W1983557750 cites W2100457862 @default.
• W1983557750 cites W2117183151 @default.
• W1983557750 cites W2117463772 @default.
• W1983557750 cites W2138179648 @default.
• W1983557750 cites W2139057316 @default.
• W1983557750 cites W2140539199 @default.
• W1983557750 cites W2146295480 @default.
• W1983557750 cites W2163647166 @default.
• W1983557750 cites W2393115371 @default.
• W1983557750 cites W2467938791 @default.
• W1983557750 cites W4211264883 @default.
• W1983557750 cites W4313335805 @default.
• W1983557750 cites W4313347687 @default.
• W1983557750 cites W83039135 @default.
• W1983557750 doi "https://doi.org/10.1111/j.1348-0421.2002.tb02704.x" @default.
• W1983557750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12139393" @default.
• W1983557750 hasPublicationYear "2002" @default.
• W1983557750 type Work @default.
• W1983557750 sameAs 1983557750 @default.
• W1983557750 citedByCount "51" @default.
• W1983557750 countsByYear W19835577502012 @default.
• W1983557750 countsByYear W19835577502013 @default.
• W1983557750 countsByYear W19835577502014 @default.
• W1983557750 countsByYear W19835577502015 @default.
• W1983557750 countsByYear W19835577502016 @default.
• W1983557750 countsByYear W19835577502017 @default.
• W1983557750 countsByYear W19835577502018 @default.
• W1983557750 countsByYear W19835577502019 @default.
• W1983557750 countsByYear W19835577502020 @default.
• W1983557750 countsByYear W19835577502021 @default.
• W1983557750 countsByYear W19835577502022 @default.
• W1983557750 countsByYear W19835577502023 @default.
• W1983557750 crossrefType "journal-article" @default.
• W1983557750 hasAuthorship W1983557750A5014332786 @default.
• W1983557750 hasAuthorship W1983557750A5020772809 @default.
• W1983557750 hasAuthorship W1983557750A5043856063 @default.
• W1983557750 hasAuthorship W1983557750A5047347247 @default.
• W1983557750 hasAuthorship W1983557750A5051420590 @default.
• W1983557750 hasAuthorship W1983557750A5084473082 @default.
• W1983557750 hasConcept C12823836 @default.
• W1983557750 hasConcept C13373296 @default.
• W1983557750 hasConcept C134018914 @default.
• W1983557750 hasConcept C153911025 @default.
• W1983557750 hasConcept C170217031 @default.
• W1983557750 hasConcept C179661763 @default.
• W1983557750 hasConcept C203014093 @default.
• W1983557750 hasConcept C2776914184 @default.
• W1983557750 hasConcept C2778690821 @default.
• W1983557750 hasConcept C2994496256 @default.
• W1983557750 hasConcept C45240729 @default.
• W1983557750 hasConcept C49039625 @default.
• W1983557750 hasConcept C501593827 @default.
• W1983557750 hasConcept C5858377 @default.
• W1983557750 hasConcept C68324877 @default.
• W1983557750 hasConcept C84913492 @default.
• W1983557750 hasConcept C86803240 @default.
• W1983557750 hasConcept C89423630 @default.
• W1983557750 hasConcept C97505648 @default.
• W1983557750 hasConceptScore W1983557750C12823836 @default.
• W1983557750 hasConceptScore W1983557750C13373296 @default.
• W1983557750 hasConceptScore W1983557750C134018914 @default.
• W1983557750 hasConceptScore W1983557750C153911025 @default.
• W1983557750 hasConceptScore W1983557750C170217031 @default.
• W1983557750 hasConceptScore W1983557750C179661763 @default.
• W1983557750 hasConceptScore W1983557750C203014093 @default.
• W1983557750 hasConceptScore W1983557750C2776914184 @default.
• W1983557750 hasConceptScore W1983557750C2778690821 @default.
• W1983557750 hasConceptScore W1983557750C2994496256 @default.
• W1983557750 hasConceptScore W1983557750C45240729 @default.

• next