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- W1983568404 abstract "The effect of genistein on osteoclast-like cell formation in mouse marrow culture in vitro was investigated. The bone marrow cells were cultured for 7 days in α-minimal essential medium containing a well-known bone resorbing agent [parathyroid hormone (1–34) (PTH), prostaglandin E2 (PGE2), 1,25-dihydroxyvitamin D3 (VD3), or lipopolysaccharide (LPS)] with an effective concentration. Osteoclast-like cell formation was estimated by staining for tartrate-resistant acid phosphatase (TRACP), a marker enzyme of osteoclasts. The presence of PTH (10−8 M), PGE2 (10−6 M), VD3 (10−8 M), or LPS (1 μg/mL) induced a remarkable increase in osteoclast-like multinucleated cells. These increases were inhibited significantly in the presence of genistein (10−7 to 10−5 M). The inhibitory effect of genistein (10−5 M) was equal to that of 17 β-estradiol (10−8 M), calcitonin (10−9 M), or zinc sulfate (10−5 M). Genistein (10−5 M) significantly inhibited dibutyryl cyclic adenosine monophosphate (10−5 M)-induced osteoclast-like cell formation. However, genistein (10−5 M) did not inhibit phorbol 12-myristate 13-acetate-induced osteoclast-like cell formation. The present study demonstrated that genistein has a potent inhibitory effect on osteoclast-like cell formation in mouse marrow culture. The inhibitory action of genistein may involve in cyclic AMP signaling." @default.
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- W1983568404 title "Inhibitory effect of genistein on osteoclast-like cell formation in mouse marrow cultures" @default.
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- W1983568404 doi "https://doi.org/10.1016/s0006-2952(99)00162-8" @default.
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