FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983571173> ?p ?o ?g. }

• W1983571173 endingPage "99" @default.
• W1983571173 startingPage "85" @default.
• W1983571173 abstract "Plasma membrane calcium ATPase isoforms (PMCAs) are expressed in a wide variety of tissues where cell‐specific expression provides ample opportunity for functional diversity amongst these transporters. The PMCAs use energy derived from ATP to extrude submicromolar concentrations of intracellular Ca 2+ ([Ca 2+ ] i ) out of the cell. Their high affinity for Ca 2+ and the speed with which they remove [Ca 2+ ] i depends upon splicing at their carboxy (C)‐terminal site. Here we provide biochemical and functional evidence that a brain‐specific, C‐terminal truncated and therefore fast variant of PMCA2, PMCA2a, has a role at hippocampal CA3 synapses. PMCA2a was enriched in forebrain synaptosomes, and in hippocampal CA3 it colocalized with the presynaptic marker proteins synaptophysin and the vesicular glutamate transporter 1, but not with the postsynaptic density protein PSD‐95. PMCA2a also did not colocalize with glutamic acid decarboxylase‐65, a marker of GABA‐ergic terminals, although it did localize to a small extent with parvalbumin‐positive presumed inhibitory terminals. Pharmacological inhibition of PMCA increased the frequency but not the amplitude of mEPSCs with little effect on mIPSCs or paired‐pulse depression of evoked IPSCs. However, inhibition of PMCA activity did enhance the amplitude and slowed the recovery of paired‐pulse facilitation (PPF) of evoked EPSCs. These results indicated that fast PMCA2a‐mediated clearance of [Ca 2+ ] i from presynaptic excitatory terminals regulated excitatory synaptic transmission within hippocampal CA3." @default.
• W1983571173 created "2016-06-24" @default.
• W1983571173 creator A5002194816 @default.
• W1983571173 creator A5020027389 @default.
• W1983571173 creator A5044646507 @default.
• W1983571173 creator A5055890012 @default.
• W1983571173 date "2007-02-12" @default.
• W1983571173 modified "2023-10-16" @default.
• W1983571173 title "Presynaptic plasma membrane Ca²⁺ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3" @default.
• W1983571173 cites W1484324228 @default.
• W1983571173 cites W1503250866 @default.
• W1983571173 cites W1535112832 @default.
• W1983571173 cites W1538448197 @default.
• W1983571173 cites W1582986153 @default.
• W1983571173 cites W1603617892 @default.
• W1983571173 cites W1605242131 @default.
• W1983571173 cites W1798409403 @default.
• W1983571173 cites W1972144214 @default.
• W1983571173 cites W1974953982 @default.
• W1983571173 cites W1978053844 @default.
• W1983571173 cites W1979841513 @default.
• W1983571173 cites W1983062910 @default.
• W1983571173 cites W1993627833 @default.
• W1983571173 cites W1999227355 @default.
• W1983571173 cites W2001423136 @default.
• W1983571173 cites W2001926755 @default.
• W1983571173 cites W2005850068 @default.
• W1983571173 cites W2007431616 @default.
• W1983571173 cites W2010041995 @default.
• W1983571173 cites W2012458221 @default.
• W1983571173 cites W2017239156 @default.
• W1983571173 cites W2025764899 @default.
• W1983571173 cites W2026665944 @default.
• W1983571173 cites W2026716749 @default.
• W1983571173 cites W2038330825 @default.
• W1983571173 cites W2043857209 @default.
• W1983571173 cites W204475490 @default.
• W1983571173 cites W2055837629 @default.
• W1983571173 cites W2058094541 @default.
• W1983571173 cites W2058869509 @default.
• W1983571173 cites W2060759606 @default.
• W1983571173 cites W2062550145 @default.
• W1983571173 cites W2065342518 @default.
• W1983571173 cites W2068476801 @default.
• W1983571173 cites W2070685419 @default.
• W1983571173 cites W2072565124 @default.
• W1983571173 cites W2080846302 @default.
• W1983571173 cites W2107235750 @default.
• W1983571173 cites W2107321441 @default.
• W1983571173 cites W2112927743 @default.
• W1983571173 cites W2117018607 @default.
• W1983571173 cites W2117088111 @default.
• W1983571173 cites W2140298693 @default.
• W1983571173 cites W2145050378 @default.
• W1983571173 cites W2146319595 @default.
• W1983571173 cites W2157846298 @default.
• W1983571173 cites W2309512786 @default.
• W1983571173 cites W2340467807 @default.
• W1983571173 cites W4230133166 @default.
• W1983571173 cites W4232102158 @default.
• W1983571173 cites W4232182652 @default.
• W1983571173 doi "https://doi.org/10.1113/jphysiol.2006.123901" @default.
• W1983571173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2075377" @default.
• W1983571173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17170045" @default.
• W1983571173 hasPublicationYear "2007" @default.
• W1983571173 type Work @default.
• W1983571173 sameAs 1983571173 @default.
• W1983571173 citedByCount "51" @default.
• W1983571173 countsByYear W19835711732012 @default.
• W1983571173 countsByYear W19835711732013 @default.
• W1983571173 countsByYear W19835711732014 @default.
• W1983571173 countsByYear W19835711732015 @default.
• W1983571173 countsByYear W19835711732016 @default.
• W1983571173 countsByYear W19835711732017 @default.
• W1983571173 countsByYear W19835711732018 @default.
• W1983571173 countsByYear W19835711732019 @default.
• W1983571173 countsByYear W19835711732020 @default.
• W1983571173 countsByYear W19835711732021 @default.
• W1983571173 countsByYear W19835711732022 @default.
• W1983571173 crossrefType "journal-article" @default.
• W1983571173 hasAuthorship W1983571173A5002194816 @default.
• W1983571173 hasAuthorship W1983571173A5020027389 @default.
• W1983571173 hasAuthorship W1983571173A5044646507 @default.
• W1983571173 hasAuthorship W1983571173A5055890012 @default.
• W1983571173 hasBestOaLocation W19835711732 @default.
• W1983571173 hasConcept C112592302 @default.
• W1983571173 hasConcept C130316041 @default.
• W1983571173 hasConcept C148762608 @default.
• W1983571173 hasConcept C148785051 @default.
• W1983571173 hasConcept C169760540 @default.
• W1983571173 hasConcept C170493617 @default.
• W1983571173 hasConcept C17077164 @default.
• W1983571173 hasConcept C181199279 @default.
• W1983571173 hasConcept C185592680 @default.
• W1983571173 hasConcept C200170125 @default.
• W1983571173 hasConcept C23265538 @default.
• W1983571173 hasConcept C41625074 @default.
• W1983571173 hasConcept C51705589 @default.

• next