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• W1983593669 startingPage "2009" @default.
• W1983593669 abstract "Aging is associated with impaired scavenging of reactive oxygen species (ROS). Here, we show that TAp73, a p53 family member, protects against aging by regulating mitochondrial activity and preventing ROS accumulation. TAp73-null mice show more pronounced aging with increased oxidative damage and senescence. TAp73 deletion reduces cellular ATP levels, oxygen consumption, and mitochondrial complex IV activity, with increased ROS production and oxidative stress sensitivity. We show that the mitochondrial complex IV subunit cytochrome C oxidase subunit 4 ( Cox4i1 ) is a direct TAp73 target and that Cox4i1 knockdown phenocopies the cellular senescence of TAp73-null cells. Results indicate that TAp73 affects mitochondrial respiration and ROS homeostasis, thus regulating aging." @default.
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• W1983593669 date "2012-09-15" @default.
• W1983593669 modified "2023-10-14" @default.
• W1983593669 title "TAp73 depletion accelerates aging through metabolic dysregulation" @default.
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• W1983593669 doi "https://doi.org/10.1101/gad.197640.112" @default.
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