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- W1983606295 abstract "Tubulin-binding cofactor A (TBCA) participates in microtubule formation, a key process in eukaryotic biology to create the cytoskeleton. There is little information on how TBCA might interact with β-tubulin en route to microtubule biogenesis. To address this, the protozoan Leishmania major was targeted as a model system. The crystal structure of TBCA and comparisons with three orthologous proteins are presented. The presence of conserved features infers that electrostatic interactions that are likely to involve the C-terminal tail of β-tubulin are key to association. This study provides a reagent and template to support further work in this area." @default.
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- W1983606295 date "2015-04-21" @default.
- W1983606295 modified "2023-10-18" @default.
- W1983606295 title "The structure of tubulin-binding cofactor A from<i>Leishmania major</i>infers a mode of association during the early stages of microtubule assembly" @default.
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- W1983606295 doi "https://doi.org/10.1107/s2053230x15000990" @default.
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