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- W1983609971 abstract "Inspired by the unique bending property of a cisplatin cross-linked DNA with high-mobility group box proteins (such as HMGB1), we designed and synthesized novel oligonucleotides (ODNs) containing a cyclic 2‘-deoxyuridylate dimer which possesses an alkylene linkage as a “clasp” with various lengths. The newly synthesized ODNs were revealed to have the deep bending property with HMGB1 A-box protein binding ability. This strategy could provide ready access to systematic preparations of structurally altered ODNs, which would be a useful system for studying structure-specific DNA recognition. Of great significance is this single-point modification of DNA, which results in significant global alteration of the structural features of DNA to acquire new functions." @default.
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- W1983609971 date "2007-08-01" @default.
- W1983609971 modified "2023-09-27" @default.
- W1983609971 title "Modular Bent DNAs: A New Class of Artificial DNAs with a Protein Binding Ability" @default.
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- W1983609971 doi "https://doi.org/10.1021/ja071335k" @default.
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