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- W1983629507 abstract "Introduction: From clinical cases, we experience that high drug plasma levels and certain specific CYP450 genotypes are associated with a higher risk for serious adverse drug reactions (SADR). However, there exist no prospective studies in the psychiatric setting to confirm this. Objectives: To examine whether high drug concentrations and/or certain CYP2D6 genotypes are causally related with a higher SADR risk in psychiatric in-patients. Methods: We performed a case-control study in the psychiatric in-patient hospital Königsfelden with 62 SADR cases and 82 (matched) controls. Matching was performed for the imputed drug (combination), gender and age group (<65 or ≥65 years old). For all cases and controls, drug plasma levels were analysed, and CYP2D6 genotyping and a midazolam tests were performed. For certain drug combinations matching proved difficult, therefore the statistical analyses used unmatched case control methodology. Results: The cases and controls were similar in age, sex, medication and also in weight, BMI, renal function and smoking behaviour. However, the odds ratio for drug plasma levels ≥120% of the upper reference limit was 3.49 (CI95: 1.42–8.57; (p=0.005)) in SADR patients compared to the control patients. SADR patients had more often a CYP2D6 poor metaboliser genotype, controls more often a CYP2D6 ultrarapid genotype (ns). Conclusions: Larger studies with more patients could show, whether our results can be confirmed. Possibly a matched case-control study would be more feasible with a multi-centre approach in order to find cases and matched controls in a timelier manner." @default.
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- W1983629507 date "2012-09-14" @default.
- W1983629507 modified "2023-09-25" @default.
- W1983629507 title "Matched case-control study: therapeutic drug monitoring in pharmacovigilance" @default.
- W1983629507 doi "https://doi.org/10.1055/s-0032-1326754" @default.
- W1983629507 hasPublicationYear "2012" @default.
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