FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983632279> ?p ?o ?g. }

• W1983632279 endingPage "16593" @default.
• W1983632279 startingPage "16588" @default.
• W1983632279 abstract "Centromere protein A (CENP-A) is a histone H3 variant that marks centromere location on the chromosome. To study the subunit structure and folding of human CENP-A-containing chromatin, we generated a set of nucleosomal arrays with canonical core histones and another set with CENP-A substituted for H3. At the level of quaternary structure and assembly, we find that CENP-A arrays are composed of octameric nucleosomes that assemble in a stepwise mechanism, recapitulating conventional array assembly with canonical histones. At intermediate structural resolution, we find that CENP-A-containing arrays are globally condensed relative to arrays with the canonical histones. At high structural resolution, using hydrogen-deuterium exchange coupled to mass spectrometry (H/DX-MS), we find that the DNA superhelical termini within each nucleosome are loosely connected to CENP-A, and we identify the key amino acid substitution that is largely responsible for this behavior. Also the C terminus of histone H2A undergoes rapid hydrogen exchange relative to canonical arrays and does so in a manner that is independent of nucleosomal array folding. These findings have implications for understanding CENP-A-containing nucleosome structure and higher-order chromatin folding at the centromere." @default.
• W1983632279 created "2016-06-24" @default.
• W1983632279 creator A5004155478 @default.
• W1983632279 creator A5023990046 @default.
• W1983632279 creator A5031409746 @default.
• W1983632279 creator A5042370670 @default.
• W1983632279 creator A5058551237 @default.
• W1983632279 creator A5067595543 @default.
• W1983632279 creator A5071499490 @default.
• W1983632279 creator A5082281992 @default.
• W1983632279 creator A5088641145 @default.
• W1983632279 creator A5088728504 @default.
• W1983632279 date "2011-09-26" @default.
• W1983632279 modified "2023-09-26" @default.
• W1983632279 title "Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini" @default.
• W1983632279 cites W1511595122 @default.
• W1983632279 cites W1527701197 @default.
• W1983632279 cites W1564804005 @default.
• W1983632279 cites W159674191 @default.
• W1983632279 cites W1971651847 @default.
• W1983632279 cites W1988997227 @default.
• W1983632279 cites W2003345607 @default.
• W1983632279 cites W2013711216 @default.
• W1983632279 cites W2020599848 @default.
• W1983632279 cites W2023505696 @default.
• W1983632279 cites W2026304022 @default.
• W1983632279 cites W2030023744 @default.
• W1983632279 cites W2033328077 @default.
• W1983632279 cites W2037607661 @default.
• W1983632279 cites W2041870135 @default.
• W1983632279 cites W2049912093 @default.
• W1983632279 cites W2050830515 @default.
• W1983632279 cites W2052842503 @default.
• W1983632279 cites W2053789874 @default.
• W1983632279 cites W2060073273 @default.
• W1983632279 cites W2061401851 @default.
• W1983632279 cites W2063006759 @default.
• W1983632279 cites W2066173190 @default.
• W1983632279 cites W2071391879 @default.
• W1983632279 cites W2075802914 @default.
• W1983632279 cites W2083304060 @default.
• W1983632279 cites W2088118120 @default.
• W1983632279 cites W2088929283 @default.
• W1983632279 cites W2091031681 @default.
• W1983632279 cites W2093158813 @default.
• W1983632279 cites W2099661093 @default.
• W1983632279 cites W2104481217 @default.
• W1983632279 cites W2106413052 @default.
• W1983632279 cites W2107501370 @default.
• W1983632279 cites W2112013199 @default.
• W1983632279 cites W2114078851 @default.
• W1983632279 cites W2129617454 @default.
• W1983632279 cites W2131633518 @default.
• W1983632279 cites W2131918208 @default.
• W1983632279 cites W2140388293 @default.
• W1983632279 cites W2144792857 @default.
• W1983632279 cites W2145349787 @default.
• W1983632279 cites W2157537668 @default.
• W1983632279 cites W2314152780 @default.
• W1983632279 doi "https://doi.org/10.1073/pnas.1113621108" @default.
• W1983632279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3189058" @default.
• W1983632279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21949362" @default.
• W1983632279 hasPublicationYear "2011" @default.
• W1983632279 type Work @default.
• W1983632279 sameAs 1983632279 @default.
• W1983632279 citedByCount "83" @default.
• W1983632279 countsByYear W19836322792012 @default.
• W1983632279 countsByYear W19836322792013 @default.
• W1983632279 countsByYear W19836322792014 @default.
• W1983632279 countsByYear W19836322792015 @default.
• W1983632279 countsByYear W19836322792016 @default.
• W1983632279 countsByYear W19836322792017 @default.
• W1983632279 countsByYear W19836322792018 @default.
• W1983632279 countsByYear W19836322792019 @default.
• W1983632279 countsByYear W19836322792020 @default.
• W1983632279 countsByYear W19836322792021 @default.
• W1983632279 countsByYear W19836322792022 @default.
• W1983632279 countsByYear W19836322792023 @default.
• W1983632279 crossrefType "journal-article" @default.
• W1983632279 hasAuthorship W1983632279A5004155478 @default.
• W1983632279 hasAuthorship W1983632279A5023990046 @default.
• W1983632279 hasAuthorship W1983632279A5031409746 @default.
• W1983632279 hasAuthorship W1983632279A5042370670 @default.
• W1983632279 hasAuthorship W1983632279A5058551237 @default.
• W1983632279 hasAuthorship W1983632279A5067595543 @default.
• W1983632279 hasAuthorship W1983632279A5071499490 @default.
• W1983632279 hasAuthorship W1983632279A5082281992 @default.
• W1983632279 hasAuthorship W1983632279A5088641145 @default.
• W1983632279 hasAuthorship W1983632279A5088728504 @default.
• W1983632279 hasBestOaLocation W19836322791 @default.
• W1983632279 hasConcept C10058791 @default.
• W1983632279 hasConcept C101152365 @default.
• W1983632279 hasConcept C104317684 @default.
• W1983632279 hasConcept C119599485 @default.
• W1983632279 hasConcept C12554922 @default.
• W1983632279 hasConcept C127413603 @default.
• W1983632279 hasConcept C150194340 @default.
• W1983632279 hasConcept C164974683 @default.

• next