Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983638056> ?p ?o ?g. }
- W1983638056 abstract "IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by which its intrinsically disordered region (IDR) at the carboxyl-terminus (C-tail) executes its functions. Post-translational modifications, conserved eukaryotic linear motifs and molecular recognition features present in the C-tail IDR enhance PTEN's protein-protein interactions that are required for its myriad cellular functions. PTEN primary and secondary interactomes are also enriched in IDPs, most being cancer related, revealing that PTEN functions emanate from and are nucleated by the C-tail IDR, which form pliable network-hubs. Together, PTEN higher order functional networks operate via multiple IDP-IDP interactions facilitated by its C-tail IDR. Targeting PTEN IDR and its interaction hubs emerges as a new paradigm for treatment of PTEN related pathologies." @default.
- W1983638056 created "2016-06-24" @default.
- W1983638056 creator A5000451058 @default.
- W1983638056 creator A5002302858 @default.
- W1983638056 creator A5011869206 @default.
- W1983638056 creator A5036557946 @default.
- W1983638056 creator A5083199032 @default.
- W1983638056 date "2013-06-20" @default.
- W1983638056 modified "2023-10-16" @default.
- W1983638056 title "Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility" @default.
- W1983638056 cites W1588173849 @default.
- W1983638056 cites W1898433065 @default.
- W1983638056 cites W1939083266 @default.
- W1983638056 cites W1965488063 @default.
- W1983638056 cites W1973065042 @default.
- W1983638056 cites W1975121208 @default.
- W1983638056 cites W1984723872 @default.
- W1983638056 cites W1996222881 @default.
- W1983638056 cites W1998831452 @default.
- W1983638056 cites W2009815491 @default.
- W1983638056 cites W2010045481 @default.
- W1983638056 cites W2010286320 @default.
- W1983638056 cites W2016193986 @default.
- W1983638056 cites W2017739035 @default.
- W1983638056 cites W2023557746 @default.
- W1983638056 cites W2024489653 @default.
- W1983638056 cites W2027302413 @default.
- W1983638056 cites W2030776726 @default.
- W1983638056 cites W2042234095 @default.
- W1983638056 cites W2043816461 @default.
- W1983638056 cites W2049476357 @default.
- W1983638056 cites W2052606462 @default.
- W1983638056 cites W2053820259 @default.
- W1983638056 cites W2065534861 @default.
- W1983638056 cites W2068427129 @default.
- W1983638056 cites W2076627331 @default.
- W1983638056 cites W2077582389 @default.
- W1983638056 cites W2084652316 @default.
- W1983638056 cites W2084715903 @default.
- W1983638056 cites W2085656056 @default.
- W1983638056 cites W2087154532 @default.
- W1983638056 cites W2087415885 @default.
- W1983638056 cites W2087818316 @default.
- W1983638056 cites W2087949287 @default.
- W1983638056 cites W2090216113 @default.
- W1983638056 cites W2095898968 @default.
- W1983638056 cites W2101600610 @default.
- W1983638056 cites W2102025585 @default.
- W1983638056 cites W2103533058 @default.
- W1983638056 cites W2103743266 @default.
- W1983638056 cites W2105597591 @default.
- W1983638056 cites W2114843025 @default.
- W1983638056 cites W2116298046 @default.
- W1983638056 cites W2118608964 @default.
- W1983638056 cites W2120881407 @default.
- W1983638056 cites W2129546321 @default.
- W1983638056 cites W2135087774 @default.
- W1983638056 cites W2143593035 @default.
- W1983638056 cites W2146486175 @default.
- W1983638056 cites W2147733973 @default.
- W1983638056 cites W2149441684 @default.
- W1983638056 cites W2153607816 @default.
- W1983638056 cites W2154335467 @default.
- W1983638056 cites W2155737059 @default.
- W1983638056 cites W2158116492 @default.
- W1983638056 cites W2160587188 @default.
- W1983638056 cites W2166396801 @default.
- W1983638056 cites W2168220711 @default.
- W1983638056 cites W2170296344 @default.
- W1983638056 cites W2314769262 @default.
- W1983638056 cites W2388163742 @default.
- W1983638056 cites W4210968583 @default.
- W1983638056 cites W4293001894 @default.
- W1983638056 doi "https://doi.org/10.1038/srep02035" @default.
- W1983638056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3687229" @default.
- W1983638056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23783762" @default.
- W1983638056 hasPublicationYear "2013" @default.
- W1983638056 type Work @default.
- W1983638056 sameAs 1983638056 @default.
- W1983638056 citedByCount "66" @default.
- W1983638056 countsByYear W19836380562013 @default.
- W1983638056 countsByYear W19836380562014 @default.
- W1983638056 countsByYear W19836380562015 @default.
- W1983638056 countsByYear W19836380562016 @default.
- W1983638056 countsByYear W19836380562017 @default.
- W1983638056 countsByYear W19836380562018 @default.
- W1983638056 countsByYear W19836380562019 @default.
- W1983638056 countsByYear W19836380562020 @default.
- W1983638056 countsByYear W19836380562021 @default.
- W1983638056 countsByYear W19836380562022 @default.
- W1983638056 countsByYear W19836380562023 @default.
- W1983638056 crossrefType "journal-article" @default.
- W1983638056 hasAuthorship W1983638056A5000451058 @default.
- W1983638056 hasAuthorship W1983638056A5002302858 @default.
- W1983638056 hasAuthorship W1983638056A5011869206 @default.
- W1983638056 hasAuthorship W1983638056A5036557946 @default.
- W1983638056 hasAuthorship W1983638056A5083199032 @default.
- W1983638056 hasBestOaLocation W19836380561 @default.
- W1983638056 hasConcept C104317684 @default.
- W1983638056 hasConcept C11804247 @default.