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• W1983642711 abstract "We investigated whether there is an association between serum ferritin or soluble transferrin receptor (sTfR) concentrations and coronary artery disease (CAD) or its clinical presentations. This is a case–control study that included 892 patients (664 cases with angiographically proven CAD and 228 controls without CAD). Blood was collected before angiography for determination of sTfR, ferritin and C-reactive protein (CRP). The values (median, 25th–75th percentiles) of sTfR (2.6 [2.1; 3.2] mg/l versus 2.4 [2.1; 3.0] mg/l, P=0.13) or ferritin (140.1 [74.8; 248.3] ng/ml versus 120.1 [74.9; 218.0] ng/ml, P=0.11) did not differ significantly between cases or controls. The values of sTfR in the case subjects with 1-vessel, 2-vessel, and 3-vessel CAD were: 2.4 [2.0; 3.0], 2.6 [2.0; 3.2], and 2.8 [2.2; 3.3] mg/l, respectively (P=0.003). In multivariate analysis, neither sTfR (χ2=0.14, P=0.70) nor ferritin (χ2=2.8, P=0.09) correlated independently with the presence of CAD. In case subjects with stable angina, unstable angina, and acute myocardial infarction (MI), ferritin concentrations were: 127.5 [69.5; 214.0], 138.9 [86.1; 278.0], and 175.0 [93.5; 314.5] ng/ml, respectively (P<0.001). Our results showed that serum concentrations of sTfR or ferritin do not predict the risk for coronary artery disease. In subjects with pre-existing CAD, those with more severe disease had increased levels of sTfR. Patients with CAD presenting with acute coronary syndromes showed increased levels of serum ferritin." @default.
• W1983642711 created "2016-06-24" @default.
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• W1983642711 date "2004-05-01" @default.
• W1983642711 modified "2023-10-18" @default.
• W1983642711 title "Value of serum ferritin and soluble transferrin receptor for prediction of coronary artery disease and its clinical presentations" @default.
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• W1983642711 doi "https://doi.org/10.1016/j.atherosclerosis.2004.01.011" @default.
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