Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983656219> ?p ?o ?g. }
- W1983656219 endingPage "320" @default.
- W1983656219 startingPage "293" @default.
- W1983656219 abstract "In 1997-1998, the pharmacological cyclin-dependent kinase (CDK) inhibitors (PCIs) were independently discovered to inhibit replication of human cytomegalovirus, herpes simplex virus type 1 and HIV-1. The results from small clinical trials against cancer were then suggesting that PCIs could be safe enough to be used clinically. It was thus hypothesized that PCIs could have the potential to be developed as novel antivirals targeting cellular proteins. Consequently, Antiviral Chemistry & Chemotherapy published in 2001 the first review on the potential of CDKs, and cellular proteins in general, as potential targets for antivirals. The viral functions inhibited by PCIs, or their cellular targets, were then just starting to be characterized. The antiviral spectrum of PCIs and their effects on viral disease were still mostly untested. Even their actual specificity was not yet completely characterized. In addition, cellular proteins were not accepted as valid targets for antivirals. Significant progress has been made in the last 5 years in understanding the antiviral activities of PCIs and the potential roles of cellular proteins in general as targets for antivirals. The first clinical trials of the antiviral activities of PCIs and other inhibitors of cellular protein kinases have now been scheduled. Herein, we review the progress made since the publication of the first review on PCIs as potential antiviral drugs and on CDKs, and cellular proteins in general, as potential targets for antiviral drugs. We also highlight the major issues that still need to be addressed before PCIs or other drugs targeting cellular proteins can be developed as clinical antivirals." @default.
- W1983656219 created "2016-06-24" @default.
- W1983656219 creator A5018322172 @default.
- W1983656219 creator A5039475997 @default.
- W1983656219 creator A5087189177 @default.
- W1983656219 date "2006-12-01" @default.
- W1983656219 modified "2023-10-17" @default.
- W1983656219 title "Five Years of Progress on Cyclin-Dependent Kinases and other Cellular Proteins as Potential Targets for Antiviral Drugs" @default.
- W1983656219 cites W14542710 @default.
- W1983656219 cites W1520222296 @default.
- W1983656219 cites W1536361243 @default.
- W1983656219 cites W1539096485 @default.
- W1983656219 cites W1545201063 @default.
- W1983656219 cites W1557240175 @default.
- W1983656219 cites W1673584566 @default.
- W1983656219 cites W177084162 @default.
- W1983656219 cites W1777669545 @default.
- W1983656219 cites W1802951397 @default.
- W1983656219 cites W1892302877 @default.
- W1983656219 cites W1966471370 @default.
- W1983656219 cites W1966515400 @default.
- W1983656219 cites W1968847718 @default.
- W1983656219 cites W1971140803 @default.
- W1983656219 cites W1974478882 @default.
- W1983656219 cites W1974790142 @default.
- W1983656219 cites W1976205207 @default.
- W1983656219 cites W1976224676 @default.
- W1983656219 cites W1977569407 @default.
- W1983656219 cites W1978985435 @default.
- W1983656219 cites W1979333126 @default.
- W1983656219 cites W1979400471 @default.
- W1983656219 cites W1983024867 @default.
- W1983656219 cites W1983956191 @default.
- W1983656219 cites W1987494107 @default.
- W1983656219 cites W1991575826 @default.
- W1983656219 cites W1996184524 @default.
- W1983656219 cites W1996267589 @default.
- W1983656219 cites W1996696918 @default.
- W1983656219 cites W1997101420 @default.
- W1983656219 cites W1997515096 @default.
- W1983656219 cites W1997802977 @default.
- W1983656219 cites W1999722691 @default.
- W1983656219 cites W1999866626 @default.
- W1983656219 cites W2000664052 @default.
- W1983656219 cites W2003393099 @default.
- W1983656219 cites W2005767120 @default.
- W1983656219 cites W2006054198 @default.
- W1983656219 cites W2010992064 @default.
- W1983656219 cites W2011588737 @default.
- W1983656219 cites W2014582878 @default.
- W1983656219 cites W2015939628 @default.
- W1983656219 cites W2016322829 @default.
- W1983656219 cites W2016552601 @default.
- W1983656219 cites W2016987929 @default.
- W1983656219 cites W2017471019 @default.
- W1983656219 cites W2022166282 @default.
- W1983656219 cites W2022359528 @default.
- W1983656219 cites W2023375233 @default.
- W1983656219 cites W2024680115 @default.
- W1983656219 cites W2025749921 @default.
- W1983656219 cites W2025890889 @default.
- W1983656219 cites W2030205108 @default.
- W1983656219 cites W2031907351 @default.
- W1983656219 cites W2034098922 @default.
- W1983656219 cites W2034661942 @default.
- W1983656219 cites W2035273416 @default.
- W1983656219 cites W2037280896 @default.
- W1983656219 cites W2037652830 @default.
- W1983656219 cites W2039379609 @default.
- W1983656219 cites W2040611519 @default.
- W1983656219 cites W2041518110 @default.
- W1983656219 cites W2043213848 @default.
- W1983656219 cites W2046113381 @default.
- W1983656219 cites W2047723003 @default.
- W1983656219 cites W2047889432 @default.
- W1983656219 cites W2048717039 @default.
- W1983656219 cites W2049109705 @default.
- W1983656219 cites W2052428303 @default.
- W1983656219 cites W2056114994 @default.
- W1983656219 cites W2058314877 @default.
- W1983656219 cites W2059520240 @default.
- W1983656219 cites W2060055284 @default.
- W1983656219 cites W2060734153 @default.
- W1983656219 cites W2061122432 @default.
- W1983656219 cites W2061185283 @default.
- W1983656219 cites W2068787265 @default.
- W1983656219 cites W2072468937 @default.
- W1983656219 cites W2079875841 @default.
- W1983656219 cites W2080793120 @default.
- W1983656219 cites W2081567150 @default.
- W1983656219 cites W2082267123 @default.
- W1983656219 cites W2083431033 @default.
- W1983656219 cites W2084013564 @default.
- W1983656219 cites W2084810833 @default.
- W1983656219 cites W2088120691 @default.
- W1983656219 cites W2088973810 @default.
- W1983656219 cites W2089167153 @default.
- W1983656219 cites W2089528428 @default.