Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983661438> ?p ?o ?g. }
- W1983661438 endingPage "198" @default.
- W1983661438 startingPage "193" @default.
- W1983661438 abstract "PIN1 was recently identified as a peptidyl-prolyl cis-trans isomerase (PPIase). It binds to and isomerizes specific pSer/Thr-Pro motifs and catalytically induces conformational changes after phosphorylation. PIN1 plays an important role in several cellular events, such as cell cycle progression, transcriptional regulation, RNA processing, cell proliferation and differentiation. The relationship between PIN1 and osteosarcoma has not been previously studied. In the present study, we investigated the expression pattern of PIN1 in human osteosarcoma tissues and the role of PIN1 in osteosarcoma generation and development. The expression levels of PIN1 were detected by immunohistochemistry and western blotting. Results demonstrated that the expression of PIN1, cyclin D1 and β-catenin were significantly higher in human osteosarcoma tissues compared to normal tissues. The in vitro effects of PIN1 overexpression were studied in human osteosarcoma cell lines. Adenovirus-mediated PIN1 overexpression significantly stimulated the proliferation of MG-63 and U2-OS osteosarcoma cells by 148±10.5 and 187±21.5%, respectively. In FACS analysis, U2-OS cells displayed significant levels of arrest in cell cycle progression at the G0/G1 phase. Consistent with increased cell growth, levels of cyclin D1 and cyclin E and their associated cyclin-dependent kinases, CDK4 and CDK6, were enhanced in PIN1-overexpressed cells compared with the control virus-transfected cells. When the PIN1 inhibitor juglone was added to the cells, the proliferative effects of PIN1 were abolished. These results suggest that PIN1 may play an important role in tumorigenesis and tumor progression of osteosarcoma and therefore, provide a new target for gene therapy." @default.
- W1983661438 created "2016-06-24" @default.
- W1983661438 creator A5017399924 @default.
- W1983661438 creator A5020546502 @default.
- W1983661438 creator A5021074786 @default.
- W1983661438 creator A5021529563 @default.
- W1983661438 creator A5045727148 @default.
- W1983661438 creator A5047052048 @default.
- W1983661438 creator A5073089368 @default.
- W1983661438 creator A5091852609 @default.
- W1983661438 date "2012-10-30" @default.
- W1983661438 modified "2023-10-03" @default.
- W1983661438 title "Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells" @default.
- W1983661438 cites W1587359158 @default.
- W1983661438 cites W1639582946 @default.
- W1983661438 cites W1968069432 @default.
- W1983661438 cites W1970446261 @default.
- W1983661438 cites W1985940796 @default.
- W1983661438 cites W1987909503 @default.
- W1983661438 cites W2005036368 @default.
- W1983661438 cites W2023453929 @default.
- W1983661438 cites W2024497944 @default.
- W1983661438 cites W2025720366 @default.
- W1983661438 cites W2029080338 @default.
- W1983661438 cites W2045295833 @default.
- W1983661438 cites W2050000741 @default.
- W1983661438 cites W2057312381 @default.
- W1983661438 cites W2063394559 @default.
- W1983661438 cites W2067826776 @default.
- W1983661438 cites W2070061120 @default.
- W1983661438 cites W2075125140 @default.
- W1983661438 cites W2093402539 @default.
- W1983661438 cites W2105214585 @default.
- W1983661438 cites W2105688631 @default.
- W1983661438 cites W2108179690 @default.
- W1983661438 cites W2126043496 @default.
- W1983661438 cites W2128737073 @default.
- W1983661438 cites W2145503772 @default.
- W1983661438 cites W2167837360 @default.
- W1983661438 cites W2169162804 @default.
- W1983661438 cites W2172153870 @default.
- W1983661438 cites W2410299681 @default.
- W1983661438 doi "https://doi.org/10.3892/or.2012.2112" @default.
- W1983661438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23129219" @default.
- W1983661438 hasPublicationYear "2012" @default.
- W1983661438 type Work @default.
- W1983661438 sameAs 1983661438 @default.
- W1983661438 citedByCount "15" @default.
- W1983661438 countsByYear W19836614382013 @default.
- W1983661438 countsByYear W19836614382014 @default.
- W1983661438 countsByYear W19836614382016 @default.
- W1983661438 countsByYear W19836614382017 @default.
- W1983661438 countsByYear W19836614382018 @default.
- W1983661438 countsByYear W19836614382020 @default.
- W1983661438 countsByYear W19836614382022 @default.
- W1983661438 countsByYear W19836614382023 @default.
- W1983661438 crossrefType "journal-article" @default.
- W1983661438 hasAuthorship W1983661438A5017399924 @default.
- W1983661438 hasAuthorship W1983661438A5020546502 @default.
- W1983661438 hasAuthorship W1983661438A5021074786 @default.
- W1983661438 hasAuthorship W1983661438A5021529563 @default.
- W1983661438 hasAuthorship W1983661438A5045727148 @default.
- W1983661438 hasAuthorship W1983661438A5047052048 @default.
- W1983661438 hasAuthorship W1983661438A5073089368 @default.
- W1983661438 hasAuthorship W1983661438A5091852609 @default.
- W1983661438 hasBestOaLocation W19836614381 @default.
- W1983661438 hasConcept C104317684 @default.
- W1983661438 hasConcept C120089663 @default.
- W1983661438 hasConcept C121608353 @default.
- W1983661438 hasConcept C1491633281 @default.
- W1983661438 hasConcept C153911025 @default.
- W1983661438 hasConcept C154472170 @default.
- W1983661438 hasConcept C16438837 @default.
- W1983661438 hasConcept C199649820 @default.
- W1983661438 hasConcept C199835354 @default.
- W1983661438 hasConcept C2777760704 @default.
- W1983661438 hasConcept C2781018059 @default.
- W1983661438 hasConcept C2781098309 @default.
- W1983661438 hasConcept C2781264208 @default.
- W1983661438 hasConcept C2910677434 @default.
- W1983661438 hasConcept C29537977 @default.
- W1983661438 hasConcept C502942594 @default.
- W1983661438 hasConcept C54009773 @default.
- W1983661438 hasConcept C54355233 @default.
- W1983661438 hasConcept C55493867 @default.
- W1983661438 hasConcept C555283112 @default.
- W1983661438 hasConcept C62112901 @default.
- W1983661438 hasConcept C81885089 @default.
- W1983661438 hasConcept C86803240 @default.
- W1983661438 hasConceptScore W1983661438C104317684 @default.
- W1983661438 hasConceptScore W1983661438C120089663 @default.
- W1983661438 hasConceptScore W1983661438C121608353 @default.
- W1983661438 hasConceptScore W1983661438C1491633281 @default.
- W1983661438 hasConceptScore W1983661438C153911025 @default.
- W1983661438 hasConceptScore W1983661438C154472170 @default.
- W1983661438 hasConceptScore W1983661438C16438837 @default.
- W1983661438 hasConceptScore W1983661438C199649820 @default.
- W1983661438 hasConceptScore W1983661438C199835354 @default.