FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983669063> ?p ?o ?g. }

• W1983669063 endingPage "2612" @default.
• W1983669063 startingPage "2602" @default.
• W1983669063 abstract "Abstract New vessel formation is critical for solid tumor growth and it is primarily stimulated by the most potent angiogenic factor vascular endothelial growth factor (VEGF or VEGF‐A165). VEGF promotes endothelial cell proliferation by initiating signaling cascades to increase gene transcription. Recent works showed that VEGF potently and rapidly induces expression of orphan nuclear receptor Nurr1 in endothelial cells. However, the signaling pathway for VEGF‐induced Nurr1 expression and its role in VEGF‐induced endothelial cell proliferation and angiogenic response have not been examined. In our study, we first show that VEGF significantly induces expression of Nurr1 mRNA, protein and its promoter activity in cultured endothelial cells. Furthermore, the promoter analysis shows that deletion of the putative cAMP‐responsive element binding protein (CREB) site in the proximal region of the promoter markedly reduces VEGF‐induced promoter activity whereas deletion of the upstream NF‐κB site has moderate effect. Transfection of a dominant negative CREB mutant (K‐CREB) or mutation of this putative CREB site in the Nurr1 promoter attenuates VEGF‐induced Nurr1 expression. VEGF also stimulates the binding of nuclear CREB protein to its site in the Nurr1 promoter in vitro and in vivo . Moreover, using pharmacological inhibitors and molecular approaches, we show that VEGF‐induced CREB activation is largely mediated by protein kinase C‐dependent protein kinase D activation. Finally, our data indicate that knockdown of endogenous Nurr1 expression attenuates VEGF‐induced endothelial cell proliferation, migration and in vivo matrigel angiogenesis, suggesting its potential importance in mediating VEGF‐induced tumor angiogenesis." @default.
• W1983669063 created "2016-06-24" @default.
• W1983669063 creator A5023279214 @default.
• W1983669063 creator A5047102000 @default.
• W1983669063 creator A5082064903 @default.
• W1983669063 date "2010-10-08" @default.
• W1983669063 modified "2023-10-18" @default.
• W1983669063 title "VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression: Role in VEGF-induced angiogenesis" @default.
• W1983669063 cites W1820645657 @default.
• W1983669063 cites W189480869 @default.
• W1983669063 cites W1964533512 @default.
• W1983669063 cites W1969744540 @default.
• W1983669063 cites W1973918329 @default.
• W1983669063 cites W1975672275 @default.
• W1983669063 cites W1984264347 @default.
• W1983669063 cites W1986559037 @default.
• W1983669063 cites W1991574606 @default.
• W1983669063 cites W1999549061 @default.
• W1983669063 cites W2000000541 @default.
• W1983669063 cites W2003600190 @default.
• W1983669063 cites W2005470247 @default.
• W1983669063 cites W2012390831 @default.
• W1983669063 cites W2016353159 @default.
• W1983669063 cites W2023538608 @default.
• W1983669063 cites W2027441347 @default.
• W1983669063 cites W2031061373 @default.
• W1983669063 cites W2042525168 @default.
• W1983669063 cites W2044358109 @default.
• W1983669063 cites W2052398489 @default.
• W1983669063 cites W2059362512 @default.
• W1983669063 cites W2064061221 @default.
• W1983669063 cites W2064725210 @default.
• W1983669063 cites W2066962839 @default.
• W1983669063 cites W2069043370 @default.
• W1983669063 cites W2080999802 @default.
• W1983669063 cites W2093175831 @default.
• W1983669063 cites W2107277218 @default.
• W1983669063 cites W2110453175 @default.
• W1983669063 cites W2111135552 @default.
• W1983669063 cites W2112964556 @default.
• W1983669063 cites W2113139156 @default.
• W1983669063 cites W2126018509 @default.
• W1983669063 cites W2131515450 @default.
• W1983669063 cites W2131961719 @default.
• W1983669063 cites W2137512583 @default.
• W1983669063 cites W2149001863 @default.
• W1983669063 cites W2168736535 @default.
• W1983669063 doi "https://doi.org/10.1002/ijc.25600" @default.
• W1983669063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20715116" @default.
• W1983669063 hasPublicationYear "2010" @default.
• W1983669063 type Work @default.
• W1983669063 sameAs 1983669063 @default.
• W1983669063 citedByCount "40" @default.
• W1983669063 countsByYear W19836690632012 @default.
• W1983669063 countsByYear W19836690632013 @default.
• W1983669063 countsByYear W19836690632014 @default.
• W1983669063 countsByYear W19836690632015 @default.
• W1983669063 countsByYear W19836690632016 @default.
• W1983669063 countsByYear W19836690632017 @default.
• W1983669063 countsByYear W19836690632018 @default.
• W1983669063 countsByYear W19836690632019 @default.
• W1983669063 countsByYear W19836690632020 @default.
• W1983669063 countsByYear W19836690632021 @default.
• W1983669063 countsByYear W19836690632022 @default.
• W1983669063 crossrefType "journal-article" @default.
• W1983669063 hasAuthorship W1983669063A5023279214 @default.
• W1983669063 hasAuthorship W1983669063A5047102000 @default.
• W1983669063 hasAuthorship W1983669063A5082064903 @default.
• W1983669063 hasBestOaLocation W19836690631 @default.
• W1983669063 hasConcept C104317684 @default.
• W1983669063 hasConcept C146285616 @default.
• W1983669063 hasConcept C14858245 @default.
• W1983669063 hasConcept C153911025 @default.
• W1983669063 hasConcept C1629964 @default.
• W1983669063 hasConcept C167734588 @default.
• W1983669063 hasConcept C173396325 @default.
• W1983669063 hasConcept C185592680 @default.
• W1983669063 hasConcept C2777025900 @default.
• W1983669063 hasConcept C2778608917 @default.
• W1983669063 hasConcept C2780394083 @default.
• W1983669063 hasConcept C502942594 @default.
• W1983669063 hasConcept C54009773 @default.
• W1983669063 hasConcept C54355233 @default.
• W1983669063 hasConcept C55493867 @default.
• W1983669063 hasConcept C62478195 @default.
• W1983669063 hasConcept C81885089 @default.
• W1983669063 hasConcept C86339819 @default.
• W1983669063 hasConcept C86803240 @default.
• W1983669063 hasConcept C95444343 @default.
• W1983669063 hasConceptScore W1983669063C104317684 @default.
• W1983669063 hasConceptScore W1983669063C146285616 @default.
• W1983669063 hasConceptScore W1983669063C14858245 @default.
• W1983669063 hasConceptScore W1983669063C153911025 @default.
• W1983669063 hasConceptScore W1983669063C1629964 @default.
• W1983669063 hasConceptScore W1983669063C167734588 @default.
• W1983669063 hasConceptScore W1983669063C173396325 @default.
• W1983669063 hasConceptScore W1983669063C185592680 @default.
• W1983669063 hasConceptScore W1983669063C2777025900 @default.

• next