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- W1983670174 abstract "YPERAMMONEMIA is of importance in the genesis of hepatic encephalopathy. Therapy directed toward reduction of elevations of blood ammonia has been of value in the management of this condition. Neomycin, which reduces the number of urea-forming organisms in the intestine, and hypothermia, which decreases the rate of bacterial action, have been of value in lowering blood ammonia.1,2More recently Zuidema et al have shown that monamine oxidase inhibitors are effective in the management of exogenous ammonia intoxication.3Some antihistamines are weak monamine oxidase inhibitors.4In addition, diphenhydramine (Benadryl) hydrochloride causes a reduction in the permeability and associated mitochondrial swelling of hepatic cells in several forms of liver damage in animals and lowers the mortality in murine hepatitis.5This study was performed to evaluate the effect of diphenhydramine on ammonia intoxication induced in dogs. Experiment End-to-side portacaval shunts were constructed in eight adult mongrel dogs weighing 10" @default.
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- W1983670174 date "1965-09-01" @default.
- W1983670174 modified "2023-09-26" @default.
- W1983670174 title "Diphenhydramine (Benadryl) Hydrochloride in the Treatment of Ammonia Intoxication" @default.
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- W1983670174 doi "https://doi.org/10.1001/archsurg.1965.01320150096016" @default.
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