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- W1983670897 abstract "The recent past has experienced a renaissance in tuberculosis (TB) research. New molecular biology reagents and genetic tools have been developed and whole genome sequences of Mycobacterium tuberculosis strains are now widely available. An increase in the prevalence of drug-resistant strains of M. tuberculosis has renewed focus on the development of new drugs against this millennia old disease. The identification of new targets in M. tuberculosis that might be inhibited to effectively kill the existing strains is now a global pursuit. This review summarizes recently identified targets in M. tuberculosis that have been validated beyond initial genetic identification. Advancing these defined targets for the development of inhibitors has the potential to produce new drugs with novel mechanisms of actions and benefit TB patients worldwide. The recent past has experienced a renaissance in tuberculosis (TB) research. New molecular biology reagents and genetic tools have been developed and whole genome sequences of Mycobacterium tuberculosis strains are now widely available. An increase in the prevalence of drug-resistant strains of M. tuberculosis has renewed focus on the development of new drugs against this millennia old disease. The identification of new targets in M. tuberculosis that might be inhibited to effectively kill the existing strains is now a global pursuit. This review summarizes recently identified targets in M. tuberculosis that have been validated beyond initial genetic identification. Advancing these defined targets for the development of inhibitors has the potential to produce new drugs with novel mechanisms of actions and benefit TB patients worldwide." @default.
- W1983670897 created "2016-06-24" @default.
- W1983670897 creator A5008664452 @default.
- W1983670897 date "2011-01-01" @default.
- W1983670897 modified "2023-10-03" @default.
- W1983670897 title "Novel targets in M. tuberculosis: search for new drugs" @default.
- W1983670897 cites W1521708238 @default.
- W1983670897 cites W1591852988 @default.
- W1983670897 cites W1839665474 @default.
- W1983670897 cites W1864461701 @default.
- W1983670897 cites W1964141703 @default.
- W1983670897 cites W1965598291 @default.
- W1983670897 cites W1967928264 @default.
- W1983670897 cites W1969633963 @default.
- W1983670897 cites W1973089560 @default.
- W1983670897 cites W1975396841 @default.
- W1983670897 cites W1976256007 @default.
- W1983670897 cites W1976963408 @default.
- W1983670897 cites W1982071439 @default.
- W1983670897 cites W1991855175 @default.
- W1983670897 cites W1996001643 @default.
- W1983670897 cites W2004361822 @default.
- W1983670897 cites W2005392593 @default.
- W1983670897 cites W2007097682 @default.
- W1983670897 cites W2008186432 @default.
- W1983670897 cites W2008402427 @default.
- W1983670897 cites W2009729452 @default.
- W1983670897 cites W2011128355 @default.
- W1983670897 cites W2012514866 @default.
- W1983670897 cites W2014224553 @default.
- W1983670897 cites W2014321835 @default.
- W1983670897 cites W2019835759 @default.
- W1983670897 cites W2022654406 @default.
- W1983670897 cites W2028812045 @default.
- W1983670897 cites W2031206118 @default.
- W1983670897 cites W2031339495 @default.
- W1983670897 cites W2032080946 @default.
- W1983670897 cites W2035579424 @default.
- W1983670897 cites W2036658481 @default.
- W1983670897 cites W2045825103 @default.
- W1983670897 cites W2051254928 @default.
- W1983670897 cites W2052422622 @default.
- W1983670897 cites W2053534534 @default.
- W1983670897 cites W2053867514 @default.
- W1983670897 cites W2058925610 @default.
- W1983670897 cites W2060626299 @default.
- W1983670897 cites W2065365517 @default.
- W1983670897 cites W2065542724 @default.
- W1983670897 cites W2065903108 @default.
- W1983670897 cites W2068372433 @default.
- W1983670897 cites W2069463652 @default.
- W1983670897 cites W2070190311 @default.
- W1983670897 cites W2075000963 @default.
- W1983670897 cites W2077770882 @default.
- W1983670897 cites W2078248420 @default.
- W1983670897 cites W2079716870 @default.
- W1983670897 cites W2081197421 @default.
- W1983670897 cites W2093364655 @default.
- W1983670897 cites W2094761728 @default.
- W1983670897 cites W2095924770 @default.
- W1983670897 cites W2098793988 @default.
- W1983670897 cites W2099183065 @default.
- W1983670897 cites W2102022526 @default.
- W1983670897 cites W2102545353 @default.
- W1983670897 cites W2102622156 @default.
- W1983670897 cites W2104850768 @default.
- W1983670897 cites W2105475356 @default.
- W1983670897 cites W2106382070 @default.
- W1983670897 cites W2108500436 @default.
- W1983670897 cites W2108783242 @default.
- W1983670897 cites W2110181046 @default.
- W1983670897 cites W2110530857 @default.
- W1983670897 cites W2114993703 @default.
- W1983670897 cites W2115482160 @default.
- W1983670897 cites W2116738290 @default.
- W1983670897 cites W2117987331 @default.
- W1983670897 cites W2120434743 @default.
- W1983670897 cites W2120842435 @default.
- W1983670897 cites W2125112523 @default.
- W1983670897 cites W2128482141 @default.
- W1983670897 cites W2129816077 @default.
- W1983670897 cites W2136000544 @default.
- W1983670897 cites W2138751689 @default.
- W1983670897 cites W2147404160 @default.
- W1983670897 cites W2152363872 @default.
- W1983670897 cites W2155331065 @default.
- W1983670897 cites W2157737997 @default.
- W1983670897 cites W2158023121 @default.
- W1983670897 cites W2158658436 @default.
- W1983670897 cites W2158705123 @default.
- W1983670897 cites W2159586303 @default.
- W1983670897 cites W2160175061 @default.
- W1983670897 cites W2162376892 @default.
- W1983670897 cites W2164282552 @default.
- W1983670897 cites W2167315117 @default.
- W1983670897 cites W2168568296 @default.
- W1983670897 cites W2169024001 @default.
- W1983670897 cites W2319922541 @default.