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• W1983674849 abstract "Little is known about what determines the nuclear matrix or how its reorganization is regulated during mitosis. In this study we report on a monoclonal antibody, mAb2A, which identifies a novel nuclear structure in Drosophila embryos which forms a diffuse meshwork at interphase but which undergoes a striking reorganization into a spindle-like structure during pro- and metaphase. Double labelings with α-tubulin and mAb2A antibodies demonstrate that the microtubules of the mitotic apparatus co-localize with this mAb2A labeled structure during metaphase, suggesting it may serve a role in microtubule spindle assembly and/or function during nuclear division. That the mAb2A-labeled nuclear structure is essential for cell division and/or maintenance of nuclear integrity was directly demonstrated by microinjection of mAb2A into early syncytial embryos which resulted in a disintegration of nuclear morphology and perturbation of mitosis. © 1996 Wiley-Liss, Inc." @default.
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• W1983674849 date "1996-12-01" @default.
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• W1983674849 title "Remodeling of nuclear architecture during the cell cycle inDrosophila embryos" @default.
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• W1983674849 doi "https://doi.org/10.1002/(sici)1097-4644(19961201)63:3<268::aid-jcb2>3.0.co;2-v" @default.
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