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• W1983684369 abstract "Drug-associated cues elicit conditioned responses in human drug users, and are thought to facilitate a drug-seeking behavior. Yet, little is known about how these associations are acquired, or about the specificity of the conditioned response modalities. In this study, healthy, nondependent volunteers (N=90) completed a conditioning paradigm in which they received a moderate dose of methamphetamine paired with one stimulus and placebo with another stimulus, each on two separate occasions. Their responses to these cues were measured with a behavioral preference, self-reported 'liking', emotional reactivity, and attentional bias measures, both before and after the conditioning. Following the conditioning procedure, subjects exhibited a behavioral preference, positive emotional reactivity, and attentional bias toward the methamphetamine-associated cue, compared with the placebo stimulus. In addition, subjects who reported greater positive subjective drug effects during the conditioning displayed a more robust conditioning. This work demonstrates that healthy nondependent volunteers readily acquire conditioned responses to neutral stimuli paired with a drug. The procedure has significant value to study individual variation in acquisition of conditioned responses as a possible risk factor for drug taking, and to study the neural basis of conditioned drug responses." @default.
• W1983684369 created "2016-06-24" @default.
• W1983684369 creator A5041945807 @default.
• W1983684369 creator A5091804865 @default.
• W1983684369 date "2015-01-20" @default.
• W1983684369 modified "2023-10-17" @default.
• W1983684369 title "Acquisition of Responses to a Methamphetamine-Associated Cue in Healthy Humans: Self-Report, Behavioral, and Psychophysiological Measures" @default.
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• W1983684369 doi "https://doi.org/10.1038/npp.2015.21" @default.
• W1983684369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4915257" @default.
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