FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983686907> ?p ?o ?g. }

• W1983686907 endingPage "15639" @default.
• W1983686907 startingPage "15629" @default.
• W1983686907 abstract "Microglial-related factors have been implicated in the signaling cascades that contribute to neuronal cell death in various neurodegenerative disorders. Thus, strategies that reduce microglial activation and associated neurotoxicity may have therapeutic benefit. Group II and III metabotropic glutamate receptors (mGluRs) are expressed in microglia and can modulate microglial activity in primary cell cultures. We demonstrate that the group I receptor member mGluR5 is highly expressed in primary microglial cultures and the BV2 microglial cell line. Activation of mGluR5 using the selective agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) significantly attenuates microglial activation in response to lipopolysaccharide and interferon-gamma, as indicated by a reduction in the expression of inducible nitric-oxide synthase, production of nitric oxide and tumor necrosis factor-alpha, and intracellular generation of reactive oxygen species. In addition, microglial-induced neurotoxicity is also markedly reduced by CHPG treatment. The anti-inflammatory effects of CHPG are mediated by the mGluR5 receptor, because either a selective mGluR5 antagonist or small interference RNA knockdown attenuated the actions of this drug. CHPG blocked the lipopolysaccharide-induced increase in expression and enzymatic activity of NADPH oxidase. Moreover, the protective effects of CHPG were significantly reduced when the NADPH oxidase subunits p22(phox) or gp91(phox) were knocked down by small interference RNA. These data suggest that mGluR5 represents a novel target for modulating microglial-dependent neuroinflammation, and may have therapeutic relevance for neurological disorders that exhibit microglial-mediated neurodegeneration." @default.
• W1983686907 created "2016-06-24" @default.
• W1983686907 creator A5011395603 @default.
• W1983686907 creator A5023218393 @default.
• W1983686907 creator A5031280966 @default.
• W1983686907 creator A5058767726 @default.
• W1983686907 creator A5087941071 @default.
• W1983686907 date "2009-06-01" @default.
• W1983686907 modified "2023-09-28" @default.
• W1983686907 title "Activation of Metabotropic Glutamate Receptor 5 Modulates Microglial Reactivity and Neurotoxicity by Inhibiting NADPH Oxidase" @default.
• W1983686907 cites W1495997476 @default.
• W1983686907 cites W1500418512 @default.
• W1983686907 cites W1505409727 @default.
• W1983686907 cites W1542142828 @default.
• W1983686907 cites W1568154290 @default.
• W1983686907 cites W1584960502 @default.
• W1983686907 cites W1668344921 @default.
• W1983686907 cites W1822833733 @default.
• W1983686907 cites W1968982618 @default.
• W1983686907 cites W1969065965 @default.
• W1983686907 cites W1978701902 @default.
• W1983686907 cites W1978897740 @default.
• W1983686907 cites W1980132212 @default.
• W1983686907 cites W1989077493 @default.
• W1983686907 cites W1991288075 @default.
• W1983686907 cites W1991538811 @default.
• W1983686907 cites W1995138363 @default.
• W1983686907 cites W1995145293 @default.
• W1983686907 cites W2003674452 @default.
• W1983686907 cites W2004349171 @default.
• W1983686907 cites W2007411105 @default.
• W1983686907 cites W2011619507 @default.
• W1983686907 cites W2017010915 @default.
• W1983686907 cites W2024628377 @default.
• W1983686907 cites W2035135723 @default.
• W1983686907 cites W2038814798 @default.
• W1983686907 cites W2039190334 @default.
• W1983686907 cites W2049659439 @default.
• W1983686907 cites W2050731687 @default.
• W1983686907 cites W2056311398 @default.
• W1983686907 cites W2068853878 @default.
• W1983686907 cites W2075669866 @default.
• W1983686907 cites W2079080506 @default.
• W1983686907 cites W2091043188 @default.
• W1983686907 cites W2094193890 @default.
• W1983686907 cites W2095376584 @default.
• W1983686907 cites W2096901938 @default.
• W1983686907 cites W2099179726 @default.
• W1983686907 cites W2103368328 @default.
• W1983686907 cites W2105959408 @default.
• W1983686907 cites W2117465944 @default.
• W1983686907 cites W2123548739 @default.
• W1983686907 cites W2138343392 @default.
• W1983686907 cites W2144508667 @default.
• W1983686907 cites W2145903555 @default.
• W1983686907 cites W2148153039 @default.
• W1983686907 cites W2152107705 @default.
• W1983686907 cites W2153090903 @default.
• W1983686907 cites W2155115959 @default.
• W1983686907 cites W2158211941 @default.
• W1983686907 cites W2158879871 @default.
• W1983686907 cites W2164120093 @default.
• W1983686907 cites W2325257956 @default.
• W1983686907 doi "https://doi.org/10.1074/jbc.m806139200" @default.
• W1983686907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2708859" @default.
• W1983686907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19364772" @default.
• W1983686907 hasPublicationYear "2009" @default.
• W1983686907 type Work @default.
• W1983686907 sameAs 1983686907 @default.
• W1983686907 citedByCount "98" @default.
• W1983686907 countsByYear W19836869072012 @default.
• W1983686907 countsByYear W19836869072013 @default.
• W1983686907 countsByYear W19836869072014 @default.
• W1983686907 countsByYear W19836869072015 @default.
• W1983686907 countsByYear W19836869072016 @default.
• W1983686907 countsByYear W19836869072017 @default.
• W1983686907 countsByYear W19836869072018 @default.
• W1983686907 countsByYear W19836869072019 @default.
• W1983686907 countsByYear W19836869072020 @default.
• W1983686907 countsByYear W19836869072021 @default.
• W1983686907 countsByYear W19836869072022 @default.
• W1983686907 countsByYear W19836869072023 @default.
• W1983686907 crossrefType "journal-article" @default.
• W1983686907 hasAuthorship W1983686907A5011395603 @default.
• W1983686907 hasAuthorship W1983686907A5023218393 @default.
• W1983686907 hasAuthorship W1983686907A5031280966 @default.
• W1983686907 hasAuthorship W1983686907A5058767726 @default.
• W1983686907 hasAuthorship W1983686907A5087941071 @default.
• W1983686907 hasBestOaLocation W19836869071 @default.
• W1983686907 hasConcept C170493617 @default.
• W1983686907 hasConcept C178790620 @default.
• W1983686907 hasConcept C185592680 @default.
• W1983686907 hasConcept C203014093 @default.
• W1983686907 hasConcept C2776914184 @default.
• W1983686907 hasConcept C2779491297 @default.
• W1983686907 hasConcept C2779719074 @default.
• W1983686907 hasConcept C2779830541 @default.
• W1983686907 hasConcept C29730261 @default.

• next