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- W1983693670 abstract "Because of the favourable effect of suramin, a powerful trypanocidal agent, which had been reported in patients with pulmonary tuberculosis, its action on the tubercle bacillus in vitro and on experimental tuberculosis in the mouse was investigated. Suramin was found to have no growth-inhibiting or promoting action on cultures in vitro, nor to have a therapeutic effect in the mouse. On the contrary, it increased the susceptibility of mice to both heavy and light tuberculous infections and caused the breakdown of established pulmonary tuberculosis. Furthermore, BCG multiplied more freely in the tissues of mice receiving suramin than in untreated animals. The possible mode of action of suramin in experimental tuberculosis is discussed, and it is suggested that it may alter the lipid surface of the tubercle bacilli in vivo so that they are less susceptible to destruction by the host defence system. This hypothesis is strengthened by the finding that suramin modifies the surface lipids of red blood cells." @default.
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- W1983693670 date "1956-10-01" @default.
- W1983693670 modified "2023-09-25" @default.
- W1983693670 title "Enhancement of experimental tuberculosis in the mouse by suramin" @default.
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- W1983693670 doi "https://doi.org/10.1016/s0041-3879(56)80078-0" @default.
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