Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983697977> ?p ?o ?g. }
- W1983697977 endingPage "705" @default.
- W1983697977 startingPage "699" @default.
- W1983697977 abstract "Biliopancreatic diversion with duodenal switch is a combined restrictive and malabsorptive surgical weight loss procedure. Given that this procedure introduces a bypass of the proximal small intestine, it is a suitable model for investigating the influence of the proximal intestine on drug bioavailability. Eight-hour pharmacokinetic profiles were obtained the day before surgery and again after surgery at (median) 6 weeks (range, 4-8 weeks) in 10 morbidly obese patients who were receiving treatment with 20-80 mg atorvastatin each morning. The bioavailability of atorvastatin acid was significantly increased, with a mean twofold higher AUC(0-8) after surgery (range 1.0-4.2, P = 0.001). Time to maximum plasma concentration (C(max)) increased from 1.2 h before surgery to 2.3 h after surgery (P = 0.03). The results emphasize the protective nature of the proximal small intestine against ingested exogenous compounds. Consequently, retitration to the lowest effective dose should be considered after biliopancreatic diversion with duodenal switch in the case of drugs with a high degree of intestinal first pass metabolism and a narrow therapeutic window." @default.
- W1983697977 created "2016-06-24" @default.
- W1983697977 creator A5012578202 @default.
- W1983697977 creator A5014825727 @default.
- W1983697977 creator A5024695335 @default.
- W1983697977 creator A5037568646 @default.
- W1983697977 creator A5040779079 @default.
- W1983697977 creator A5062371838 @default.
- W1983697977 creator A5079047032 @default.
- W1983697977 creator A5079260481 @default.
- W1983697977 date "2010-05-05" @default.
- W1983697977 modified "2023-10-09" @default.
- W1983697977 title "Significant Increase in Systemic Exposure of Atorvastatin After Biliopancreatic Diversion With Duodenal Switch" @default.
- W1983697977 cites W1560709301 @default.
- W1983697977 cites W1966132884 @default.
- W1983697977 cites W1966846971 @default.
- W1983697977 cites W1977182374 @default.
- W1983697977 cites W1984601088 @default.
- W1983697977 cites W1986348861 @default.
- W1983697977 cites W1990836565 @default.
- W1983697977 cites W1995285957 @default.
- W1983697977 cites W1996190454 @default.
- W1983697977 cites W2002345475 @default.
- W1983697977 cites W2014608182 @default.
- W1983697977 cites W2021805817 @default.
- W1983697977 cites W2035635857 @default.
- W1983697977 cites W2037029956 @default.
- W1983697977 cites W2037621239 @default.
- W1983697977 cites W2038338711 @default.
- W1983697977 cites W2043071325 @default.
- W1983697977 cites W2045677482 @default.
- W1983697977 cites W2049178219 @default.
- W1983697977 cites W2055018724 @default.
- W1983697977 cites W2069388748 @default.
- W1983697977 cites W2073313925 @default.
- W1983697977 cites W2075173366 @default.
- W1983697977 cites W2075584976 @default.
- W1983697977 cites W2083283764 @default.
- W1983697977 cites W2085646040 @default.
- W1983697977 cites W2086787354 @default.
- W1983697977 cites W2094278352 @default.
- W1983697977 cites W2098540102 @default.
- W1983697977 cites W2105902511 @default.
- W1983697977 cites W2110079281 @default.
- W1983697977 cites W2110791445 @default.
- W1983697977 cites W2116372743 @default.
- W1983697977 cites W2121689079 @default.
- W1983697977 cites W2147104041 @default.
- W1983697977 cites W2149444637 @default.
- W1983697977 cites W2158882111 @default.
- W1983697977 cites W2289395671 @default.
- W1983697977 cites W4232195096 @default.
- W1983697977 cites W4250752146 @default.
- W1983697977 cites W4251314584 @default.
- W1983697977 cites W4323284006 @default.
- W1983697977 doi "https://doi.org/10.1038/clpt.2010.32" @default.
- W1983697977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20445535" @default.
- W1983697977 hasPublicationYear "2010" @default.
- W1983697977 type Work @default.
- W1983697977 sameAs 1983697977 @default.
- W1983697977 citedByCount "43" @default.
- W1983697977 countsByYear W19836979772012 @default.
- W1983697977 countsByYear W19836979772013 @default.
- W1983697977 countsByYear W19836979772014 @default.
- W1983697977 countsByYear W19836979772015 @default.
- W1983697977 countsByYear W19836979772016 @default.
- W1983697977 countsByYear W19836979772017 @default.
- W1983697977 countsByYear W19836979772018 @default.
- W1983697977 countsByYear W19836979772019 @default.
- W1983697977 countsByYear W19836979772020 @default.
- W1983697977 countsByYear W19836979772021 @default.
- W1983697977 countsByYear W19836979772022 @default.
- W1983697977 countsByYear W19836979772023 @default.
- W1983697977 crossrefType "journal-article" @default.
- W1983697977 hasAuthorship W1983697977A5012578202 @default.
- W1983697977 hasAuthorship W1983697977A5014825727 @default.
- W1983697977 hasAuthorship W1983697977A5024695335 @default.
- W1983697977 hasAuthorship W1983697977A5037568646 @default.
- W1983697977 hasAuthorship W1983697977A5040779079 @default.
- W1983697977 hasAuthorship W1983697977A5062371838 @default.
- W1983697977 hasAuthorship W1983697977A5079047032 @default.
- W1983697977 hasAuthorship W1983697977A5079260481 @default.
- W1983697977 hasConcept C112705442 @default.
- W1983697977 hasConcept C126322002 @default.
- W1983697977 hasConcept C141071460 @default.
- W1983697977 hasConcept C181389837 @default.
- W1983697977 hasConcept C2776266264 @default.
- W1983697977 hasConcept C2776809568 @default.
- W1983697977 hasConcept C2777482532 @default.
- W1983697977 hasConcept C2777882243 @default.
- W1983697977 hasConcept C2908792022 @default.
- W1983697977 hasConcept C3019402062 @default.
- W1983697977 hasConcept C511355011 @default.
- W1983697977 hasConcept C544821477 @default.
- W1983697977 hasConcept C71924100 @default.
- W1983697977 hasConcept C90924648 @default.
- W1983697977 hasConcept C98274493 @default.
- W1983697977 hasConceptScore W1983697977C112705442 @default.