FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983704998> ?p ?o ?g. }

• W1983704998 abstract "Abstract Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic bone formation in the spinal ligaments. Although mechanical stress is thought to be an important factor in the progression of OPLL, the mechanism by which mechanical stress promotes the ossification of ligaments in OPLL is still unknown. Therefore, we investigated osteogenic responses induced by mechanical stress in OPLL cells and pathways required for transmitting mechanical signals in these processes. Cells obtained from spinal ligament tissues of OPLL and non-OPLL patients (NOP) were subjected to uni-axial cyclic stretch. Messenger RNA expressions of alkaline phosphatase (ALP) and osteopontin, bone morphogenetic protein-2 (BMP-2), and ALP activity in OPLL cells were significantly increased by cyclic stretch, whereas no change was observed in non-OPLL cells. Ca 2+ channel blockers suppressed stretch-induced ALP activity to resting state level. Furthermore, conditioned medium of OPLL cell cultures subjected to cyclic stretch increased the ALP activity of other OPLL cells. These results suggested that mechanical stress plays a key role in the progression of OPLL through the induction of osteogenic differentiation in ligament cells, Ca 2+ mobilization and promotion of the autocrine/paracrine mechanism of BMP-2 in this lesion." @default.
• W1983704998 created "2016-06-24" @default.
• W1983704998 creator A5003482863 @default.
• W1983704998 creator A5005731040 @default.
• W1983704998 creator A5006181270 @default.
• W1983704998 creator A5045183338 @default.
• W1983704998 creator A5058356786 @default.
• W1983704998 date "2002-07-01" @default.
• W1983704998 modified "2023-09-27" @default.
• W1983704998 title "Molecular events caused by cyclic stretch in spinal ligament cells from patients with ossification of the posterior longitudinal ligament" @default.
• W1983704998 cites W113290550 @default.
• W1983704998 cites W1521324828 @default.
• W1983704998 cites W1546173464 @default.
• W1983704998 cites W1626382598 @default.
• W1983704998 cites W1855551843 @default.
• W1983704998 cites W1968997913 @default.
• W1983704998 cites W1970060373 @default.
• W1983704998 cites W1990336362 @default.
• W1983704998 cites W1990364386 @default.
• W1983704998 cites W2002156733 @default.
• W1983704998 cites W201000630 @default.
• W1983704998 cites W2012052368 @default.
• W1983704998 cites W2014096386 @default.
• W1983704998 cites W2017378018 @default.
• W1983704998 cites W2020313885 @default.
• W1983704998 cites W2026309027 @default.
• W1983704998 cites W2026866767 @default.
• W1983704998 cites W2033711915 @default.
• W1983704998 cites W2040508169 @default.
• W1983704998 cites W2046967596 @default.
• W1983704998 cites W2056162891 @default.
• W1983704998 cites W2079446801 @default.
• W1983704998 cites W2104119940 @default.
• W1983704998 cites W2320372224 @default.
• W1983704998 cites W2409212895 @default.
• W1983704998 cites W2413570053 @default.
• W1983704998 doi "https://doi.org/10.1016/s0531-5131(02)00459-4" @default.
• W1983704998 hasPublicationYear "2002" @default.
• W1983704998 type Work @default.
• W1983704998 sameAs 1983704998 @default.
• W1983704998 citedByCount "0" @default.
• W1983704998 crossrefType "journal-article" @default.
• W1983704998 hasAuthorship W1983704998A5003482863 @default.
• W1983704998 hasAuthorship W1983704998A5005731040 @default.
• W1983704998 hasAuthorship W1983704998A5006181270 @default.
• W1983704998 hasAuthorship W1983704998A5045183338 @default.
• W1983704998 hasAuthorship W1983704998A5058356786 @default.
• W1983704998 hasConcept C105702510 @default.
• W1983704998 hasConcept C118552586 @default.
• W1983704998 hasConcept C126322002 @default.
• W1983704998 hasConcept C128240485 @default.
• W1983704998 hasConcept C170493617 @default.
• W1983704998 hasConcept C174286582 @default.
• W1983704998 hasConcept C181104049 @default.
• W1983704998 hasConcept C2776667541 @default.
• W1983704998 hasConcept C2777604421 @default.
• W1983704998 hasConcept C2778842504 @default.
• W1983704998 hasConcept C2779492255 @default.
• W1983704998 hasConcept C2779753412 @default.
• W1983704998 hasConcept C2780105995 @default.
• W1983704998 hasConcept C2780775167 @default.
• W1983704998 hasConcept C71924100 @default.
• W1983704998 hasConcept C7876069 @default.
• W1983704998 hasConcept C86803240 @default.
• W1983704998 hasConcept C95444343 @default.
• W1983704998 hasConceptScore W1983704998C105702510 @default.
• W1983704998 hasConceptScore W1983704998C118552586 @default.
• W1983704998 hasConceptScore W1983704998C126322002 @default.
• W1983704998 hasConceptScore W1983704998C128240485 @default.
• W1983704998 hasConceptScore W1983704998C170493617 @default.
• W1983704998 hasConceptScore W1983704998C174286582 @default.
• W1983704998 hasConceptScore W1983704998C181104049 @default.
• W1983704998 hasConceptScore W1983704998C2776667541 @default.
• W1983704998 hasConceptScore W1983704998C2777604421 @default.
• W1983704998 hasConceptScore W1983704998C2778842504 @default.
• W1983704998 hasConceptScore W1983704998C2779492255 @default.
• W1983704998 hasConceptScore W1983704998C2779753412 @default.
• W1983704998 hasConceptScore W1983704998C2780105995 @default.
• W1983704998 hasConceptScore W1983704998C2780775167 @default.
• W1983704998 hasConceptScore W1983704998C71924100 @default.
• W1983704998 hasConceptScore W1983704998C7876069 @default.
• W1983704998 hasConceptScore W1983704998C86803240 @default.
• W1983704998 hasConceptScore W1983704998C95444343 @default.
• W1983704998 hasLocation W19837049981 @default.
• W1983704998 hasOpenAccess W1983704998 @default.
• W1983704998 hasPrimaryLocation W19837049981 @default.
• W1983704998 hasRelatedWork W113290550 @default.
• W1983704998 hasRelatedWork W185795182 @default.
• W1983704998 hasRelatedWork W1989078473 @default.
• W1983704998 hasRelatedWork W1990364386 @default.
• W1983704998 hasRelatedWork W2001502048 @default.
• W1983704998 hasRelatedWork W2017378018 @default.
• W1983704998 hasRelatedWork W2039410576 @default.
• W1983704998 hasRelatedWork W2069059876 @default.
• W1983704998 hasRelatedWork W2079446801 @default.
• W1983704998 hasRelatedWork W2091950626 @default.
• W1983704998 hasRelatedWork W2091977479 @default.
• W1983704998 hasRelatedWork W2288752488 @default.
• W1983704998 hasRelatedWork W2365294644 @default.
• W1983704998 hasRelatedWork W2375641231 @default.

• next