Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983711229> ?p ?o ?g. }
- W1983711229 endingPage "103" @default.
- W1983711229 startingPage "94" @default.
- W1983711229 abstract "A combination of symmetric building blocks and combinatorial functional group transformation for synthesis of pyrimidines was investigated. The purpose of the study was to maximize the return on invested synthetic efforts of reaction development for libraries. A representative set of symmetric diacids was coupled onto deprotected TentaGel Rink Amide resin. The amino function served as a model of a chemical process providing a functional group for additional synthetic steps, while the symmetric building blocks served as a model to connect synthesis protocols and to switch to a different synthesis paradigm consecutively. The reaction sequence was continued in a noncombinatorial step by coupling a bifunctional reagent (3-aminoacetophenone) to the remaining carboxy function of the symmetric diacid. The ketone served as a model of a reagent prepared for combinatorial functional group transformation. The arylmethylketone was reacted with a set of aryl- and heteroarylaldehydes to give alpha,beta-unsaturated ketones. Subsequently, guanidine, alkyl-, and arylcarboxamidines were introduced in combinatorial synthesis of substituted pyrimidines by reaction with the alpha, beta-unsaturated ketone functionality. The combination of symmetric building blocks and combinatorial functional group transformation created a versatile reaction sequence ideally suited for production of libraries from libraries with added diversity." @default.
- W1983711229 created "2016-06-24" @default.
- W1983711229 creator A5006253166 @default.
- W1983711229 creator A5037775787 @default.
- W1983711229 creator A5077207286 @default.
- W1983711229 date "2000-01-01" @default.
- W1983711229 modified "2023-09-27" @default.
- W1983711229 title "Symmetric building blocks and combinatorial functional group transformation as versatile strategies in combinatorial chemistry" @default.
- W1983711229 cites W1603311386 @default.
- W1983711229 cites W1985583908 @default.
- W1983711229 cites W1989809283 @default.
- W1983711229 cites W1996234424 @default.
- W1983711229 cites W1997104342 @default.
- W1983711229 cites W2004610998 @default.
- W1983711229 cites W2013726060 @default.
- W1983711229 cites W2013947915 @default.
- W1983711229 cites W2032681246 @default.
- W1983711229 cites W2033542073 @default.
- W1983711229 cites W2034413905 @default.
- W1983711229 cites W2035092588 @default.
- W1983711229 cites W2040788688 @default.
- W1983711229 cites W2047566559 @default.
- W1983711229 cites W2050912145 @default.
- W1983711229 cites W2051454037 @default.
- W1983711229 cites W2056422776 @default.
- W1983711229 cites W2061371635 @default.
- W1983711229 cites W2064476610 @default.
- W1983711229 cites W2072719700 @default.
- W1983711229 cites W2077396048 @default.
- W1983711229 cites W2080784258 @default.
- W1983711229 cites W2084128951 @default.
- W1983711229 cites W2089571021 @default.
- W1983711229 cites W2093044967 @default.
- W1983711229 cites W2093197480 @default.
- W1983711229 cites W2113364144 @default.
- W1983711229 cites W2118468123 @default.
- W1983711229 cites W2119559217 @default.
- W1983711229 cites W2123259105 @default.
- W1983711229 cites W2126127010 @default.
- W1983711229 cites W2129963908 @default.
- W1983711229 cites W2151670440 @default.
- W1983711229 cites W2171386360 @default.
- W1983711229 cites W2179148317 @default.
- W1983711229 cites W2489575089 @default.
- W1983711229 cites W2914210023 @default.
- W1983711229 cites W2916451683 @default.
- W1983711229 cites W2949650697 @default.
- W1983711229 cites W2949678656 @default.
- W1983711229 cites W2949680497 @default.
- W1983711229 cites W2950238768 @default.
- W1983711229 cites W4248107770 @default.
- W1983711229 cites W4302403725 @default.
- W1983711229 cites W4319308389 @default.
- W1983711229 cites W68182257 @default.
- W1983711229 doi "https://doi.org/10.1002/1097-0290(200021)71:2<94::aid-bit3>3.0.co;2-y" @default.
- W1983711229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11288063" @default.
- W1983711229 hasPublicationYear "2000" @default.
- W1983711229 type Work @default.
- W1983711229 sameAs 1983711229 @default.
- W1983711229 citedByCount "2" @default.
- W1983711229 countsByYear W19837112292013 @default.
- W1983711229 crossrefType "journal-article" @default.
- W1983711229 hasAuthorship W1983711229A5006253166 @default.
- W1983711229 hasAuthorship W1983711229A5037775787 @default.
- W1983711229 hasAuthorship W1983711229A5077207286 @default.
- W1983711229 hasConcept C161790260 @default.
- W1983711229 hasConcept C178790620 @default.
- W1983711229 hasConcept C185592680 @default.
- W1983711229 hasConcept C18903297 @default.
- W1983711229 hasConcept C21951064 @default.
- W1983711229 hasConcept C2777332933 @default.
- W1983711229 hasConcept C2777738585 @default.
- W1983711229 hasConcept C2778112365 @default.
- W1983711229 hasConcept C2778439535 @default.
- W1983711229 hasConcept C2780263894 @default.
- W1983711229 hasConcept C2780443040 @default.
- W1983711229 hasConcept C2781076698 @default.
- W1983711229 hasConcept C2781311116 @default.
- W1983711229 hasConcept C2988890453 @default.
- W1983711229 hasConcept C40875361 @default.
- W1983711229 hasConcept C521977710 @default.
- W1983711229 hasConcept C55493867 @default.
- W1983711229 hasConcept C86803240 @default.
- W1983711229 hasConceptScore W1983711229C161790260 @default.
- W1983711229 hasConceptScore W1983711229C178790620 @default.
- W1983711229 hasConceptScore W1983711229C185592680 @default.
- W1983711229 hasConceptScore W1983711229C18903297 @default.
- W1983711229 hasConceptScore W1983711229C21951064 @default.
- W1983711229 hasConceptScore W1983711229C2777332933 @default.
- W1983711229 hasConceptScore W1983711229C2777738585 @default.
- W1983711229 hasConceptScore W1983711229C2778112365 @default.
- W1983711229 hasConceptScore W1983711229C2778439535 @default.
- W1983711229 hasConceptScore W1983711229C2780263894 @default.
- W1983711229 hasConceptScore W1983711229C2780443040 @default.
- W1983711229 hasConceptScore W1983711229C2781076698 @default.
- W1983711229 hasConceptScore W1983711229C2781311116 @default.
- W1983711229 hasConceptScore W1983711229C2988890453 @default.
- W1983711229 hasConceptScore W1983711229C40875361 @default.