Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983714966> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1983714966 endingPage "348A" @default.
- W1983714966 startingPage "348A" @default.
- W1983714966 abstract "The capability of creating stenotic lesions in an animal model is essential to testing new interventional devices. We developed a coronary stenosis model in domestic swine using either heated balloon angioplasty (heat) at high-temperature (80 °C for 15 seconds) or copper stents (copper). Animals were sacrificed 14–47 days after artery injury. Morphometric and histologic study of the stenoses created by heat (14 pigs, 33 arteries) and copper (9 pigs, 18 arteries) was performed. Measurement of lumen area and area circumscribed by the internal elastic lamina (IEL) was used to calculate stenosis by l-(lumen/IEL). Mean stenosis from heat was 66.9 ± 27% and copper 80.7 ± 22%. Stenoses exceeding 50% were produced by heat 78.8% and copper stents 87.5% of the time. Histologically, the heat group was notable for concentric intimal hyperplasia, intact elastic laminae, necrosis of medial cells, calcific deposits in the media, and mild adventitial inflammation and fibrosis. Copper stent lesions demonstrated severe diffuse inflammation, destruction of the elastic laminae, neovascularization, and mild intimal calcification around stent tines.Percent of Arteries with Histologic FeatureEmpty CellInflammationCalcificationNeovascularFibrosisNecrosisHCHCHCHCHCIntima3%90%‡3%50%‡3%65%‡3%50%‡11%5%Media25%95%‡22%5%11%63%‡8%74%‡69%26%*Adventitia69%70%11%5%17%40%‡64%55%11%5%Fisher's Exact Test, two-sided:*p ≤ 0.05,‡p ≤ 0.0001 H = Heat C = Copper Percent of Arteries with Histologic Feature Fisher's Exact Test, two-sided: p ≤ 0.05, p ≤ 0.0001 H = Heat C = Copper Heated balloon angioplasty or deployment of copper stents into swine coronary arteries reliably creates severe stenoses suitable for testing new interventional devices. Copper stents in particular create very tight and complicated lesions that would challenge new devices. The histopathology differs with copper demonstrating destructive inflammatory lesions vs. orderly intimal hyperplasia and medial calcification observed in heat lesions." @default.
- W1983714966 created "2016-06-24" @default.
- W1983714966 creator A5036611987 @default.
- W1983714966 creator A5044282374 @default.
- W1983714966 creator A5045846939 @default.
- W1983714966 creator A5051142287 @default.
- W1983714966 creator A5074893722 @default.
- W1983714966 creator A5079123919 @default.
- W1983714966 creator A5086188803 @default.
- W1983714966 date "1995-02-01" @default.
- W1983714966 modified "2023-09-26" @default.
- W1983714966 title "1001-28 Stenotic Lesions Reliably Form in Porcine Coronary Arteries Using Copper Stents or Intracoronary Heating" @default.
- W1983714966 doi "https://doi.org/10.1016/0735-1097(95)92902-h" @default.
- W1983714966 hasPublicationYear "1995" @default.
- W1983714966 type Work @default.
- W1983714966 sameAs 1983714966 @default.
- W1983714966 citedByCount "2" @default.
- W1983714966 crossrefType "journal-article" @default.
- W1983714966 hasAuthorship W1983714966A5036611987 @default.
- W1983714966 hasAuthorship W1983714966A5044282374 @default.
- W1983714966 hasAuthorship W1983714966A5045846939 @default.
- W1983714966 hasAuthorship W1983714966A5051142287 @default.
- W1983714966 hasAuthorship W1983714966A5074893722 @default.
- W1983714966 hasAuthorship W1983714966A5079123919 @default.
- W1983714966 hasAuthorship W1983714966A5086188803 @default.
- W1983714966 hasConcept C126322002 @default.
- W1983714966 hasConcept C126838900 @default.
- W1983714966 hasConcept C131631996 @default.
- W1983714966 hasConcept C139059822 @default.
- W1983714966 hasConcept C141071460 @default.
- W1983714966 hasConcept C142724271 @default.
- W1983714966 hasConcept C164705383 @default.
- W1983714966 hasConcept C191897082 @default.
- W1983714966 hasConcept C192562407 @default.
- W1983714966 hasConcept C2776205367 @default.
- W1983714966 hasConcept C2776820930 @default.
- W1983714966 hasConcept C2778583881 @default.
- W1983714966 hasConcept C2778742706 @default.
- W1983714966 hasConcept C2779751240 @default.
- W1983714966 hasConcept C2780007028 @default.
- W1983714966 hasConcept C2780309369 @default.
- W1983714966 hasConcept C2780326628 @default.
- W1983714966 hasConcept C2992686903 @default.
- W1983714966 hasConcept C544778455 @default.
- W1983714966 hasConcept C71924100 @default.
- W1983714966 hasConceptScore W1983714966C126322002 @default.
- W1983714966 hasConceptScore W1983714966C126838900 @default.
- W1983714966 hasConceptScore W1983714966C131631996 @default.
- W1983714966 hasConceptScore W1983714966C139059822 @default.
- W1983714966 hasConceptScore W1983714966C141071460 @default.
- W1983714966 hasConceptScore W1983714966C142724271 @default.
- W1983714966 hasConceptScore W1983714966C164705383 @default.
- W1983714966 hasConceptScore W1983714966C191897082 @default.
- W1983714966 hasConceptScore W1983714966C192562407 @default.
- W1983714966 hasConceptScore W1983714966C2776205367 @default.
- W1983714966 hasConceptScore W1983714966C2776820930 @default.
- W1983714966 hasConceptScore W1983714966C2778583881 @default.
- W1983714966 hasConceptScore W1983714966C2778742706 @default.
- W1983714966 hasConceptScore W1983714966C2779751240 @default.
- W1983714966 hasConceptScore W1983714966C2780007028 @default.
- W1983714966 hasConceptScore W1983714966C2780309369 @default.
- W1983714966 hasConceptScore W1983714966C2780326628 @default.
- W1983714966 hasConceptScore W1983714966C2992686903 @default.
- W1983714966 hasConceptScore W1983714966C544778455 @default.
- W1983714966 hasConceptScore W1983714966C71924100 @default.
- W1983714966 hasIssue "2" @default.
- W1983714966 hasLocation W19837149661 @default.
- W1983714966 hasOpenAccess W1983714966 @default.
- W1983714966 hasPrimaryLocation W19837149661 @default.
- W1983714966 hasRelatedWork W1965692986 @default.
- W1983714966 hasRelatedWork W1969298735 @default.
- W1983714966 hasRelatedWork W1971006200 @default.
- W1983714966 hasRelatedWork W1984804049 @default.
- W1983714966 hasRelatedWork W2043694720 @default.
- W1983714966 hasRelatedWork W2083935741 @default.
- W1983714966 hasRelatedWork W2087075515 @default.
- W1983714966 hasRelatedWork W2127204175 @default.
- W1983714966 hasRelatedWork W2168269261 @default.
- W1983714966 hasRelatedWork W3148399651 @default.
- W1983714966 hasVolume "25" @default.
- W1983714966 isParatext "false" @default.
- W1983714966 isRetracted "false" @default.
- W1983714966 magId "1983714966" @default.
- W1983714966 workType "article" @default.