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- W1983720494 abstract "Primary biliary cirrhosis is a chronic inflammatory process that mainly affects the medium-sized intrahepatic bile ducts, leads to chronic cholestasis, and often progresses to cirrhosis and liver failure which requires liver transplantation. The only approved drug for primary biliary cirrhosis is ursodeoxycholic acid, a natural bile acid, which can stop or slowdown the activity of the disease if given early in the course. 1 Poupon R Poupon RE Primary biliary cirrhosis. in: Zakim D Boyer TD Hepatology: a textbook of liver disease. 3rd edn. WB Saunders Company, Philadelphia1996: 1329-1365 Google Scholar Primary biliary cirrhosis is thought of as an autoimmune disease because it is closely associated with various immunological abnormalities, the hallmark being the presence of antimitochondrial antibodies in over 95% of patients. The epitope recognised by autoreactive CD4+ and CD8+ T cells is similar to that recognised by the autoantibody. B-cell and helper and cytotoxic T-cell immunodominant epitopes contain a shared peptide sequence within the inner lipoyl domain of the E2 component of pyruvate dehydrogenase (PDC E2), a well-conserved enzyme located on the inner mitochondrial membrane." @default.
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- W1983720494 date "2004-01-01" @default.
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- W1983720494 title "Retrovirus infection as a trigger for primary biliary cirrhosis?" @default.
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- W1983720494 doi "https://doi.org/10.1016/s0140-6736(03)15418-9" @default.
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