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• W198372057 startingPage "1381" @default.
• W198372057 abstract "That sleep deprivation increases the brain expression of various clock genes has been well documented. Based on these and other findings we hypothesized that clock genes not only underlie circadian rhythm generation but are also implicated in sleep homeostasis. However, long time lags have been reported between the changes in the clock gene messenger RNA levels and their encoded proteins. It is therefore crucial to establish whether also protein levels increase within the time frame known to activate a homeostatic sleep response. We report on the central and peripheral effects of sleep deprivation on PERIOD-2 (PER2) protein both in intact and suprachiasmatic nuclei-lesioned mice. In vivo and in situ PER2 imaging during baseline, sleep deprivation, and recovery. Mouse sleep-recording facility. Per2::Luciferase knock-in mice. N/A. Six-hour sleep deprivation increased PER2 not only in the brain but also in liver and kidney. Remarkably, the effects in the liver outlasted those observed in the brain. Within the brain the increase in PER2 concerned the cerebral cortex mainly, while leaving suprachiasmatic nuclei (SCN) levels unaffected. Against expectation, sleep deprivation did not increase PER2 in the brain of arrhythmic SCN-lesioned mice because of higher PER2 levels in baseline. In contrast, liver PER2 levels did increase in these mice similar to the sham and partially lesioned controls. Our results stress the importance of considering both sleep-wake dependent and circadian processes when quantifying clock-gene levels. Because sleep deprivation alters PERIOD-2 in the brain as well as in the periphery, it is tempting to speculate that clock genes constitute a common pathway mediating the shared and well-known adverse effects of both chronic sleep loss and disrupted circadian rhythmicity on metabolic health." @default.
• W198372057 created "2016-06-24" @default.
• W198372057 creator A5025774397 @default.
• W198372057 creator A5054974059 @default.
• W198372057 creator A5060210983 @default.
• W198372057 creator A5085281832 @default.
• W198372057 date "2015-09-01" @default.
• W198372057 modified "2023-10-18" @default.
• W198372057 title "In Vivo Imaging of the Central and Peripheral Effects of Sleep Deprivation and Suprachiasmatic Nuclei Lesion on PERIOD-2 Protein in Mice" @default.
• W198372057 cites W137552884 @default.
• W198372057 cites W1541117554 @default.
• W198372057 cites W1671705759 @default.
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• W198372057 cites W1966285890 @default.
• W198372057 cites W1987546711 @default.
• W198372057 cites W1987605400 @default.
• W198372057 cites W1992621596 @default.
• W198372057 cites W1996172219 @default.
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• W198372057 cites W2004914129 @default.
• W198372057 cites W2007438633 @default.
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• W198372057 cites W2012944830 @default.
• W198372057 cites W2014234042 @default.
• W198372057 cites W2014313900 @default.
• W198372057 cites W2021203820 @default.
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• W198372057 doi "https://doi.org/10.5665/sleep.4974" @default.
• W198372057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4531406" @default.
• W198372057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25581923" @default.
• W198372057 hasPublicationYear "2015" @default.
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