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- W1983733845 abstract "The interferon regulatory factor 1 (IRF-1) acts as a transcriptional inducer of the interferon beta (IFN-beta) gene and interferon-stimulated genes. Here we report that IRF-1-mediated IFN-beta induction depends on NFkappaB activity. IRF-1 by itself initiates NFkappaB activation by inducing a reduction in cellular MAD3/IkappaBalpha, an inhibitor of NFkappaB. After nuclear translocation, NFkappaB synergizes with IRF-1 on the cis-elements positive regulatory domain (PRD)II and PRDI/III to induce transcription of the IFN-beta gene. In contrast with IFN-beta transcription induced by dsRNA or virus, c-Jun/ATF-2 binding to PRDIV is not involved. Recombinant MAD3/IkappaBalpha is phosphorylated in vitro by extracts from IRF-1-expressing cells. IRF-1-dependent MAD3/IkappaBalpha degradation is not detectable in cells expressing a dominant negative mutant of the protein kinase PKR, suggesting that PKR mediates MAD3/IkappaBalpha degradation." @default.
- W1983733845 created "2016-06-24" @default.
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- W1983733845 creator A5091704443 @default.
- W1983733845 date "1999-04-01" @default.
- W1983733845 modified "2023-09-26" @default.
- W1983733845 title "NFkappaB activation is required for interferon regulatory factor-1-mediated interferon beta induction" @default.
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- W1983733845 doi "https://doi.org/10.1046/j.1432-1327.1999.00308.x" @default.
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