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- W1983737022 abstract "Abstract Earlier observations on the reaction of some 2-naphthylamine metabolites with thiols have been extended. 2-Amino-1-naphthyl sulphate, bis -(2-amino-1-naphthyl)-hydrogen phosphate and 2-amino-1-naphthyl glucosiduronic acid arylate N -acetylcysteine and glutathione at pH 7.0 at 37° to give the corresponding S -(2-amino-1-naphthyl) derivatives. These metabolites may therefore not be inert excretion products. N -Formyl, N -acetyl and N -sulpho derivatives do not appear to react. 2-Methylamino-and 2-dimethylamino-1-naphthyl sulphates and 3-methyl-2-amino-1-naphthyl sulphate react with the thiols. Bis -(2-nitro-1-naphthyl)-hydrogen phosphate reacts to give 2-nitro- and 2-amino-1-naphthyl derivatives. No reaction was observed between some other o -aminoaryl sulphates and thiols. The reaction is discussed in relation to the metabolism and carcinogenicity of aromatic amines." @default.
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- W1983737022 date "1972-06-01" @default.
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- W1983737022 title "Arylation of thiols by 2-amino-1-naphthol derivatives and related compounds" @default.
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- W1983737022 doi "https://doi.org/10.1016/0009-2797(72)90046-4" @default.
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