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- W1983740892 abstract "Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is a plasma membrane protein carrying intra- and inter-molecular disulfide bonds and an N-linked glycan. Both disulfide bond formation and N-glycosylation are critical check points determining the stability and degradation fate of ABCG2 protein in the endoplasmic reticulum (ER). Misfolded ABCG2 protein without those post-translational modifications is removed from the ER by retrotranslocation to the cytosol compartment, ubiquitination by ubiquitin ligase, and finally degradation by proteasomes. Certain non-synonymous SNP variants of ABCG2 undergo such ER-associated degradation (ERAD)." @default.
- W1983740892 created "2016-06-24" @default.
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- W1983740892 date "2009-01-01" @default.
- W1983740892 modified "2023-10-09" @default.
- W1983740892 title "Quality control of human ABCG2 protein in the endoplasmic reticulum: Ubiquitination and proteasomal degradation" @default.
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- W1983740892 doi "https://doi.org/10.1016/j.addr.2008.08.008" @default.
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