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- W1983741516 abstract "The possibility that P2X₇ receptor (P2X₇R) expression in microglia would mediate neuronal damage via reactive oxygen species (ROS) production was examined in the APPswe/PS1dE9 mouse model of Alzheimer's disease (AD). P2X7R was predominantly expressed in CD11b-immunopositive microglia from 3 months of age before Abeta plaque formation. In addition, gp91phox, a catalytic subunit of NADPH oxidase, and ethidium fluorescence were detected in P2X₇R-positive microglial cells of animals at 6 months of age, indicating that P2X₇R-positive microglia could produce ROS. Postsynaptic density 95-positive dendrites showed significant damage in regions positive for P2X₇R in the cerebral cortex of 6 month-old mice. Taken together, up-regulation of P2X₇R activation and ROS production in microglia are parallel with Aβ increase and correlate with synaptotoxicity in AD." @default.
- W1983741516 created "2016-06-24" @default.
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- W1983741516 date "2011-01-01" @default.
- W1983741516 modified "2023-10-14" @default.
- W1983741516 title "Microglial P2X<sub>7</sub>receptor expression is accompanied by neuronal damage in the cerebral cortex of the APP<sub>swe</sub>/PS1dE9 mouse model of Alzheimer's disease" @default.
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- W1983741516 doi "https://doi.org/10.3858/emm.2011.43.1.001" @default.
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