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- W1983742241 endingPage "4710" @default.
- W1983742241 startingPage "4700" @default.
- W1983742241 abstract "The combined effects of cholesterol, a major cell membrane component, and the lipid second messenger diacylglycerol on the activity of protein kinase C (PK-C) and the structure of phosphatidylcholine/phosphatidylserine bilayers were investigated using specific PK-C assays and 2H NMR. Whereas the classical activation of PK-C was observed as an effect of diacylglycerol, in the absence of this second messenger, cholesterol did not affect PK-C activity. A novel effect of amplified PK-C activation was observed in the presence of both cholesterol and diacylglycerol concentrations within the physiological range of each of these components. 2H NMR results suggest that this phenomenon is due to cholesterol- and diacylglycerol-induced increased propensity of the lipids to adopt nonbilayer phases, effectively destabilizing the bilayer structure. The magnitude of the effect was a function of cholesterol concentration, implying that laterally separated cell membrane domains with distinct cholesterol concentrations have the capacity to differ in their sensitivity to extracellular stimuli." @default.
- W1983742241 created "2016-06-24" @default.
- W1983742241 creator A5028394360 @default.
- W1983742241 creator A5066335093 @default.
- W1983742241 date "2008-06-01" @default.
- W1983742241 modified "2023-10-16" @default.
- W1983742241 title "Amplification of Diacylglycerol Activation of Protein Kinase C by Cholesterol" @default.
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- W1983742241 doi "https://doi.org/10.1529/biophysj.107.121426" @default.
- W1983742241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2397349" @default.
- W1983742241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18326666" @default.