FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983749500> ?p ?o ?g. }

• W1983749500 endingPage "706" @default.
• W1983749500 startingPage "697" @default.
• W1983749500 abstract "Clinical trials have revealed that progression of immunoglobulin A nephropathy (IgAN), the most common form of human glomerulonephritis, is inhibited by dietary (n-3) polyunsaturated fatty acid (PUFA) supplementation. The early stages of IgAN can be mimicked by feeding mice the mycotoxin deoxynivalenol (DON). Here, the effects of consuming the (n-3) PUFA eicosapentaenoic acid (EPA) on DON-induced IgAN were assessed relative to dose dependency and to expression of interleukin (IL-6). In the dose-response study, weight gain and feed intake did not differ among mice consuming 20 ppm DON supplemented with 0%, 0.1%, 0.5% and 3% EPA for 16 weeks. Mice fed the two highest EPA concentrations exhibited markedly increased splenic EPA, docosapentaenoic acid and docosahexaenoic acid, whereas arachidonic acid was decreased in all three EPA fed groups. Deoxynivalenol consumption significantly increased serum IgA and IgA immune complexes as well as kidney mesangial IgA deposition. All three IgAN markers were attenuated in mice fed 3% EPA diet but not in those fed 0.1% or 0.5% EPA. Elevated IgA production was observed in spleen and Peyer's patch (PP) cell cultures derived from mice fed DON in control diets, but this was reduced in cultures from mice fed 0.1%, 0.5% and 3% EPA. Acute DON exposure increased serum levels of IL-6, a cytokine that drives differentiation of IgA-committed B cells to IgA secretion. Relatedly, expression of IL-6 mRNA and IL-6 heteronuclear RNA, a marker of IL-6 transcription, was increased in spleen and PP. All three indicators of IL-6 expression were suppressed in mice consuming 3% EPA. Suppressed IL-6 corresponded to decreased binding activity of two factors that regulate transcription of this cytokine, cyclic AMP response element-binding protein and activator protein-1. The results indicate that a threshold existed for EPA relative to suppression of experimental IgAN and that the threshold dose was effective at inhibiting IL-6 transcription." @default.
• W1983749500 created "2016-06-24" @default.
• W1983749500 creator A5060677752 @default.
• W1983749500 creator A5089007798 @default.
• W1983749500 date "2006-10-01" @default.
• W1983749500 modified "2023-10-16" @default.
• W1983749500 title "Attenuation of mycotoxin-induced IgA nephropathy by eicosapentaenoic acid in the mouse: dose response and relation to IL-6 expression" @default.
• W1983749500 cites W142717363 @default.
• W1983749500 cites W1766651653 @default.
• W1983749500 cites W1831301545 @default.
• W1983749500 cites W1970585261 @default.
• W1983749500 cites W1976892347 @default.
• W1983749500 cites W1979796455 @default.
• W1983749500 cites W1981219870 @default.
• W1983749500 cites W1985076614 @default.
• W1983749500 cites W1989812164 @default.
• W1983749500 cites W1992668137 @default.
• W1983749500 cites W2000304758 @default.
• W1983749500 cites W2004808033 @default.
• W1983749500 cites W2013159479 @default.
• W1983749500 cites W2015333250 @default.
• W1983749500 cites W2028354609 @default.
• W1983749500 cites W2037087465 @default.
• W1983749500 cites W2044844590 @default.
• W1983749500 cites W2045394065 @default.
• W1983749500 cites W2047389018 @default.
• W1983749500 cites W2051511807 @default.
• W1983749500 cites W2052102726 @default.
• W1983749500 cites W2052620776 @default.
• W1983749500 cites W2053582362 @default.
• W1983749500 cites W2055651239 @default.
• W1983749500 cites W2060915333 @default.
• W1983749500 cites W2064573608 @default.
• W1983749500 cites W2072807452 @default.
• W1983749500 cites W2080758552 @default.
• W1983749500 cites W2080760412 @default.
• W1983749500 cites W2082661957 @default.
• W1983749500 cites W2083033324 @default.
• W1983749500 cites W2084346279 @default.
• W1983749500 cites W2085423049 @default.
• W1983749500 cites W2086877812 @default.
• W1983749500 cites W2087886138 @default.
• W1983749500 cites W2091802065 @default.
• W1983749500 cites W2097196982 @default.
• W1983749500 cites W2099187662 @default.
• W1983749500 cites W2103161616 @default.
• W1983749500 cites W2108284804 @default.
• W1983749500 cites W2111304767 @default.
• W1983749500 cites W2112105480 @default.
• W1983749500 cites W2122486350 @default.
• W1983749500 cites W2126151205 @default.
• W1983749500 cites W2126237198 @default.
• W1983749500 cites W2138021054 @default.
• W1983749500 cites W2143888757 @default.
• W1983749500 cites W2149422934 @default.
• W1983749500 cites W2149540111 @default.
• W1983749500 cites W2156077651 @default.
• W1983749500 cites W2164856533 @default.
• W1983749500 cites W2164880881 @default.
• W1983749500 cites W2166796353 @default.
• W1983749500 cites W2398137194 @default.
• W1983749500 cites W2404202914 @default.
• W1983749500 cites W2411318522 @default.
• W1983749500 cites W3023533824 @default.
• W1983749500 cites W2184087457 @default.
• W1983749500 doi "https://doi.org/10.1016/j.jnutbio.2005.12.002" @default.
• W1983749500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16524712" @default.
• W1983749500 hasPublicationYear "2006" @default.
• W1983749500 type Work @default.
• W1983749500 sameAs 1983749500 @default.
• W1983749500 citedByCount "32" @default.
• W1983749500 countsByYear W19837495002012 @default.
• W1983749500 countsByYear W19837495002013 @default.
• W1983749500 countsByYear W19837495002014 @default.
• W1983749500 countsByYear W19837495002015 @default.
• W1983749500 countsByYear W19837495002016 @default.
• W1983749500 countsByYear W19837495002017 @default.
• W1983749500 countsByYear W19837495002018 @default.
• W1983749500 countsByYear W19837495002019 @default.
• W1983749500 countsByYear W19837495002021 @default.
• W1983749500 countsByYear W19837495002022 @default.
• W1983749500 crossrefType "journal-article" @default.
• W1983749500 hasAuthorship W1983749500A5060677752 @default.
• W1983749500 hasAuthorship W1983749500A5089007798 @default.
• W1983749500 hasConcept C126322002 @default.
• W1983749500 hasConcept C134018914 @default.
• W1983749500 hasConcept C181199279 @default.
• W1983749500 hasConcept C185592680 @default.
• W1983749500 hasConcept C19038510 @default.
• W1983749500 hasConcept C203014093 @default.
• W1983749500 hasConcept C2776091944 @default.
• W1983749500 hasConcept C2777171753 @default.
• W1983749500 hasConcept C2778078955 @default.
• W1983749500 hasConcept C2778690821 @default.
• W1983749500 hasConcept C2779102806 @default.
• W1983749500 hasConcept C2780898057 @default.
• W1983749500 hasConcept C2780931953 @default.
• W1983749500 hasConcept C2781184683 @default.

• next