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• W1983754328 endingPage "4387" @default.
• W1983754328 startingPage "4378" @default.
• W1983754328 abstract "Relatively little progress has been made in determining the in vivo regulation of glutathione S-transferase P (GSTP), particularly the human enzyme hGSTP1, despite being identified as a significant factor in carcinogenesis and development of drug resistance in tumor cell lines. Here, we report the characterization of a transgenic reporter mouse that reveals how hGSTP1 is regulated in vivo by chemopreventive agents. Basal expression was found in crypts and villi of the small and large intestine, bronchiolar epithelial cells, the epidermis and hair follicles, gall bladder epithelium, choroid plexus, and biliary epithelium. Expression was induced in different tissues by the antioxidant chemopreventive agents ethoxyquin and butylated hydroxyanisole. However, genetic deletion of the Nrf2 transcription factor, which directs central genetic programs of detoxification and protection against oxidative stress, increased rather than attenuated GSTP1 expression. In vitro investigations with mouse embryonic fibroblasts revealed factors, in addition to Nrf2, that control the expression of GSTP1, offering further insights into regulation. The new reporter mouse described here provides a useful tool to gain deeper insights into the mechanisms of action of chemopreventive compounds and other environmental agents." @default.
• W1983754328 created "2016-06-24" @default.
• W1983754328 creator A5017811816 @default.
• W1983754328 creator A5035792835 @default.
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• W1983754328 date "2014-08-13" @default.
• W1983754328 modified "2023-09-25" @default.
• W1983754328 title "<i>In Vivo</i> Regulation of Human Glutathione Transferase GSTP by Chemopreventive Agents" @default.
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• W1983754328 doi "https://doi.org/10.1158/0008-5472.can-14-0792" @default.
• W1983754328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4134684" @default.
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• W1983754328 hasPublicationYear "2014" @default.
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