Matches in SemOpenAlex for { <https://semopenalex.org/work/W1983754627> ?p ?o ?g. }
- W1983754627 abstract "Comorbidity is a major issue in psychiatry that notably associates with more severe symptoms, longer illness duration and higher service utilization. Therefore, identifying key clusters of comorbidity and exploring the underlying pathophysiological mechanisms represent important steps towards improving mental health care. In the present review, we focus on the frequent association between addiction and depression. In particular, we summarize the large body of evidence from preclinical models indicating that the kappa opioid receptor (KOR), a member of the opioid neuromodulatory system, represents a central player in the regulation of both reward and mood processes. Current data suggest that the KOR modulates overlapping neuronal networks linking brainstem monoaminergic nuclei with forebrain limbic structures. Rewarding properties of both drugs of abuse and natural stimuli, as well as the neurobiological effects of stressful experiences, strongly interact at the level of KOR signalling. In addiction models, activity of the KOR is potentiated by stressors and critically controls drug-seeking and relapse. In depression paradigms, KOR signalling is responsive to a variety of stressors, and mediates despair-like responses. Altogether, the KOR represents a prototypical substrate of comorbidity, whereby life experiences converge upon common brain mechanisms to trigger behavioural dysregulation and increased risk for distinct but interacting psychopathologies." @default.
- W1983754627 created "2016-06-24" @default.
- W1983754627 creator A5031112700 @default.
- W1983754627 creator A5038986194 @default.
- W1983754627 creator A5060945719 @default.
- W1983754627 creator A5072154774 @default.
- W1983754627 date "2014-12-08" @default.
- W1983754627 modified "2023-10-17" @default.
- W1983754627 title "The Kappa Opioid Receptor: From Addiction to Depression, and Back" @default.
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